ArticleGenome biology2002
The repertoire of protein kinases encoded in the draft version of the human genome: atypical variations and uncommon domain combinations.
Article in Genome biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
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- Recognition of sites of functional specialisation in all known eukaryotic protein kinase families.PLoS computational biology · 2018Article
- Inhibition of protein kinases by anticancer DNA intercalator, 4-butylaminopyrimido[4',5':4,5]thieno(2,3-Acta pharmaceutica Sinica. B · 2017Article
- Computational identification and analysis of neurodegenerative disease associated protein kinases in hominid genomes.Genes & diseases · 2016Article
- Article
- Antibody Microarray Analysis of Signaling Networks Regulated by Cxcl13 and Cxcr5 in Prostate Cancer.Journal of proteomics & bioinformatics · 2012Article
- Repertoire of Protein Kinases Encoded in the Genome of Takifugu rubripes.Comparative and functional genomics · 2012Article
- Classification of protein kinases on the basis of both kinase and non-kinase regions.PloS one · 2010Article
- Functional diversity of human protein kinase splice variants marks significant expansion of human kinome.BMC genomics · 2009Article
- Reengineering the signaling properties of a Src family kinase.Biochemistry · 2009Article
- Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates.PloS one · 2009Article
- Classification of nonenzymatic homologues of protein kinases.Comparative and functional genomics · 2009Article
- Comparative kinomics of human and chimpanzee reveal unique kinship and functional diversity generated by new domain combinations.BMC genomics · 2008Article
- Evidence for a minimal eukaryotic phosphoproteome?PloS one · 2007Article
- Computational Biology and Bioinformatics: a tinge of Indian spice.Bioinformation · 2006Article
- Systematic analysis of human kinase genes: a large number of genes and alternative splicing events result in functional and structural diversity.BMC bioinformatics · 2005Article
- Diversity in domain architectures of Ser/Thr kinases and their homologues in prokaryotes.BMC genomics · 2005Article
- KinG: a database of protein kinases in genomes.Nucleic acids research · 2004Article
- Genomic analysis of the eukaryotic protein kinase superfamily: a perspective.Genome biology · 2003Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPhosphorylation by protein kinases is central to cellular signal transduction. Abnormal functioning of kinases has been implicated in developmental disorders and malignancies. Their activity is regulated by second messengers and by the binding of associated domains, which are also influential in translocating the catalytic component to their substrate sites, in mediating interaction with other proteins and carrying out their biological roles.
resultUsing sensitive profile-search methods and manual analysis, the human genome has been surveyed for protein kinases. A set of 448 sequences, which show significant similarity to protein kinases and contain the critical residues essential for kinase function, have been selected for an analysis of domain combinations after classifying the kinase domains into subfamilies. The unusual domain combinations in particular kinases suggest their involvement in ubiquitination pathways and alternative modes of regulation for mitogen-activated protein kinase kinases (MAPKKs) and cyclin-dependent kinase (CDK)-like kinases. Previously unexplored kinases have been implicated in osteoblast differentiation and embryonic development on the basis of homology with kinases of known functions from other organisms. Kinases potentially unique to vertebrates are involved in highly evolved processes such as apoptosis, protein translation and tyrosine kinase signaling. In addition to coevolution with the kinase domain, duplication and recruitment of non-catalytic domains is apparent in signaling domains such as the PH, DAG-PE, SH2 and SH3 domains.
conclusionsExpansion of the functional repertoire and possible existence of alternative modes of regulation of certain kinases is suggested by their uncommon domain combinations. Experimental verification of the predicted implications of these kinases could enhance our understanding of their biological roles.
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