SynthesisThe Cochrane database of systematic reviews2003
Non-invasive positive pressure ventilation for treatment of respiratory failure due to exacerbations of chronic obstructive pulmonary disease.
Synthesis in The Cochrane database of systematic reviews, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Non-invasive positive pressure ventilation for treatment of respiratory failure due to severe acute exacerbations of asthma.The Cochrane database of systematic reviews · 2012Pooled it
- Respiratory failure in patients undergoing allogeneic hematopoietic SCT--a randomized trial on early non-invasive ventilation based on standard care hematology wards.Bone marrow transplantation · 2012Trial
- Analysis of pH, electrolytes and non-invasive respiratory support in COPD with elevated COBioinformation · 2024Article
- How should we monitor patients with acute respiratory failure treated with noninvasive ventilation?European respiratory review : an official journal of the European Respiratory Society · 2018Review
- Outcomes of Noninvasive and Invasive Ventilation in Patients Hospitalized with Asthma Exacerbation.Annals of the American Thoracic Society · 2016Article
- [Hypercapnic respiratory failure. Pathophysiology, indications for mechanical ventilation and management].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2016Review
- Hospitals' Patterns of Use of Noninvasive Ventilation in Patients With Asthma Exacerbation.Chest · 2016Article
- Performance of noninvasive ventilation in acute respiratory failure in critically ill patients: a prospective, observational, cohort study.BMC pulmonary medicine · 2015Observational
- Always consider the possibility of opioid induced respiratory depression in patients presenting with hypercapnic respiratory failure who fail to improve as expected with appropriate therapy.Case reports in critical care · 2015Article
- Variability in Nose-to-Lung Aerosol Delivery.Journal of aerosol science · 2014Article
- Improving the lung delivery of nasally administered aerosols during noninvasive ventilation-an application of enhanced condensational growth (ECG).Journal of aerosol medicine and pulmonary drug delivery · 2011Article
- Bench-to-bedside review: Resuscitation in the emergency department.Critical care (London, England) · 2005Review
- [New therapeutic approaches to COPD].Der Internist · 2004Article
- Brazilian recommendations of mechanical ventilation 2013. Part I.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e TisilogiaReview
- Brazilian recommendations of mechanical ventilation 2013. Part I.Revista Brasileira de terapia intensivaReview
Corrections and comments
- Updated by
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNon-invasive positive pressure ventilation (NPPV) is being used increasingly in the management of patients admitted to hospital with acute respiratory failure secondary to an exacerbation of chronic obstructive pulmonary disease (COPD).
objectivesTo determine the effectiveness of NPPV in the management of patients with respiratory failure due to an acute exacerbation of COPD. SEARCH STRATEGY: An initial search was performed using the Cochrane Airways Group trials register and other relevant electronic databases. SELECTION CRITERIA: Randomised controlled trials comparing NPPV plus usual medical care versus usual medical care alone were selected. Trials needed to recruit adult patients admitted to hospital with respiratory failure due to an exacerbation of COPD and with PaCO2 > 6 kPa (45 mmHg). DATA COLLECTION AND ANALYSIS: Two reviewers independently selected articles for inclusion, evaluated methodological quality of the studies and abstracted the data. MAIN
resultsEight studies were included in the review. NPPV resulted in decreased mortality (Relative Risk [RR] 0.41; 95% Confidence Intervals [CI] 0.26, 0.64), decreased need for intubation (RR 0.42; 95%CI 0.31, 0.59), reduction in treatment failure (RR 0.51; 95%CI 0.39, 0.67), rapid improvement within the first hour in pH (Weight Mean Difference [WMD] 0.03; 95%CI 0.02, 0.04), PaCO2 (WMD -0.40 kPa; 95%CI -0.78, -0.03) and respiratory rate (WMD -3.08 bpm; 95%CI -4.26, -1.89). In addition, complications associated with treatment (RR 0.32; 95%CI 0.18, 0.56) and length of hospital stay (WMD -3.24 days; 95%CI -4.42, -2.06) were also reduced in the NPPV group. REVIEWER'S
conclusionsData from good quality randomised controlled trials permit NPPV to be recommended as the first line intervention, coupled with usual medical care, in all suitable patients with respiratory failure secondary to an acute exacerbation of COPD. A trial of NPPV should be considered early in the course of respiratory failure, and before severe acidosis ensures, as a means of avoiding endotracheal intubation, reducing mortality and treatment failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.