SynthesisThe Cochrane database of systematic reviews2003
Treatment for primary postpartum haemorrhage.
Synthesis in The Cochrane database of systematic reviews, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Treatment for primary postpartum haemorrhage.The Cochrane database of systematic reviews · 2014Pooled it
- Medical treatment for early fetal death (less than 24 weeks).The Cochrane database of systematic reviews · 2006Pooled it
- A new removable uterine compression suture (RUCS) as an effective treatment for postpartum hemorrhage without long-term uterine synechiae: a retrospective preliminary study.BMC pregnancy and childbirth · 2026Article
- Article
- Rapid Absorption of Dry-Powder Intranasal Oxytocin.Pharmaceutical research · 2016Article
- The uterine sandwich method for placenta previa accreta in mullerian anomaly: combining the B-lynch compression suture and an intrauterine gauze tampon.Case reports in obstetrics and gynecology · 2013Article
- Uterine compression sutures as an effective treatment for postpartum hemorrhage: case series.AJP reports · 2011Article
- B-Lynch suture technique to control postpartum hemorrhage in a patient with mullerian anomaly.Journal of the Turkish German Gynecological Association · 2011Article
- Variations in policies for management of the third stage of labour and the immediate management of postpartum haemorrhage in Europe.BJOG : an international journal of obstetrics and gynaecology · 2007Article
- Active management of third stage of labour saves facility costs in Guatemala and Zambia.Journal of health, population, and nutrition · 2006Article
- Uterovaginal packing with rolled gauze in postpartum hemorrhage.MedGenMed : Medscape general medicine · 2004Article
Corrections and comments
- Updated by
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrimary postpartum haemorrhage is one of the top five causes of maternal mortality in both developed and developing countries.
objectivesThe objective of this review was to assess the effectiveness and safety of pharmacological and surgical interventions used for the treatment of primary postpartum haemorrhage. SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth Group's trials register (April 2002). SELECTION CRITERIA: Randomised or quasi-randomised controlled trials comparing pharmacological, surgical and radiological interventions for the treatment of primary postpartum haemorrhage. DATA COLLECTION AND ANALYSIS: Studies were assessed for eligibility and quality by reviewers independently. Data were extracted into pre-specified data sheets. Authors of the included study were contacted for more information. Analysis was by intention to treat. Results are presented as relative risk with 95% confidence intervals using the fixed effects model. MAIN
resultsOne trial, comparing rectally administered misoprostol versus syntometrine combined with an oxytocin infusion, met the eligibility criteria and was included in the review. It was not large enough to evaluate the effects of rectal misoprostol on maternal mortality, serious maternal morbidity or hysterectomy rates in women with primary postpartum haemorrhage. Compared with a combination of intramuscular syntometrine injection and oxytocin infusion, rectal misoprostol administration showed a statistically significant reduction in the number of women who continued to bleed after the intervention and those who required medical co-interventions to control the bleeding (6% versus 34%) (relative risk 0.18, 95% confidence interval 0.04 to 0.67). However, there was no significant difference between the two groups regarding surgical interventions to control intractable haemorrhage including hysterectomy, internal iliac artery ligation and/or uterine packing. REVIEWER'S
conclusionsRectal misoprostol in a dose of 800 micrograms could be a useful 'first line' drug for the treatment of primary postpartum haemorrhage. Further randomised controlled trials are required to identify the best drug combinations, route, and dose for the treatment of postpartum haemorrhage.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.