ArticleGenesis (New York, N.Y. : 2000)2003
Expression of conditional cre recombinase in epithelial tissues of transgenic mice.
Article in Genesis (New York, N.Y. : 2000), 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- Subepithelial telocytes are an important source of Wnts that supports intestinal crypts.Nature · 2018Article
- Von Hippel-Lindau status influences phenotype of liver cancers arising from PTEN loss.Gastrointestinal cancer : targets and therapy · 2015Article
- Reduced prostate branching morphogenesis in stromal fibroblast, but not in epithelial, estrogen receptor α knockout mice.Asian journal of andrology · 2012Article
- B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity.Science (New York, N.Y.) · 2012Article
- Article
- Epithelial cell-targeted transgene expression enables isolation of cyan fluorescent protein (CFP)-expressing prostate stem/progenitor cells.Transgenic research · 2011Article
- Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy.The Journal of biological chemistry · 2010Article
- The critical role of epithelial-derived Act1 in IL-17- and IL-25-mediated pulmonary inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Conditional gene recombination by adenovirus-driven Cre in the mouse uterus.Genesis (New York, N.Y. : 2000) · 2006Article
- Differential sensitivity of mouse epithelial tissues to the polyomavirus middle T oncogene.The American journal of pathology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
summaryKeratin 18 (K18) expression is a defining characteristic of internal epithelial cells of mammals. Here, we used the K18 gene and an internal ribosome entry site (IRES) to express green fluorescent protein, human placental alkaline phosphatase, and a modified Cre recombinase in an epithelial specific pattern in transgenic mice. The K18-driven alkaline phosphatase was expressed in liver, kidney, uterine endometrium, and other internal epithelia. The enzymatic activity of the Cre recombinase-mutant estrogen receptor fusion protein was dependent on tamoxifen administration and resulted in a mosaic pattern in internal epithelia, including bladder, uterus, liver, and kidney. This conditional Cre activity in internal epithelial organs should be valuable for strategies utilizing Cre for activation of gene expression. This study demonstrates that the tissue-specific, position-independent transcriptional activity of the K18 gene is not compromised by the use of an IRES element for the expression of a second protein from a bicistronic mRNA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.