ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Characterization of the circuits that generate spontaneous episodes of activity in the early embryonic mouse spinal cord.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.
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Who cites it
112 citing papers in PubMed, 273 citations in OpenAlex.
- Redefining the central pattern generator for vertebrate locomotion.Nature reviews. Neuroscience · 2026Review
- Prolonged Light Exposure Induces Long-Lasting Retinal Wave Plasticity via Retrograde Melanopsin-Dopamine Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Spontaneous enteric nervous system activity generates contractile patterns prior to maturation of gastrointestinal motility.Neurogastroenterology and motility · 2026Article
- Spinal maps of motoneuron activity during human locomotion: neuromechanical considerations.Frontiers in physiology · 2024Review
- Higher Dose Noninvasive Transcutaneous Auricular Vagus Nerve Stimulation Increases Feeding Volumes and White Matter Microstructural Complexity in Open-Label Study of Infants Slated for Gastrostomy Tube.The Journal of pediatrics · 2023Article
- Isoform requirement of clustered protocadherin for preventing neuronal apoptosis and neonatal lethality.iScience · 2023Article
- Chronic, episodic nicotine exposure alters GABAergic synaptic transmission to hypoglossal motor neurons and genioglossus muscle function at a critical developmental age.Journal of neurophysiology · 2022Article
- Production of human spinal-cord organoids recapitulating neural-tube morphogenesis.Nature biomedical engineering · 2022Article
- Motoneuronal Regulation of Central Pattern Generator and Network Function.Advances in neurobiology · 2022Article
- Chloride Homeostasis in Developing Motoneurons.Advances in neurobiology · 2022Article
- A single motor neuron determines the rhythm of early motor behavior inScience advances · 2021Article
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- Dynamic regulation of the cholinergic system in the spinal central nervous system.Scientific reports · 2020Article
- Article
- Single-Cell Reconstruction of Emerging Population Activity in an Entire Developing Circuit.Cell · 2019Article
- Feedback to the future: motor neuron contributions to central pattern generator function.The Journal of experimental biology · 2019Review
- A supervised machine learning approach to characterize spinal network function.Journal of neurophysiology · 2019Article
- Feedback regulation of locomotion by motoneurons in the vertebrate spinal cord.Current opinion in physiology · 2019Article
- Developmental plasticity of GABAergic neurotransmission to brainstem motoneurons.The Journal of physiology · 2018Article
- Persistent Sodium Current Drives Excitability of Immature Renshaw Cells in Early Embryonic Spinal Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
52 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In the developing nervous system, patterned spontaneous activity affects a variety of developmental processes. Thus, it is important to identify the earliest time that such activity occurs and to characterize the underlying circuitry. In isolated mouse spinal cord-limb preparations, highly rhythmic spontaneous activity occurred as early as embryonic day 11 (E11)-E12, when many lumbosacral motoneurons were still migrating and extending their peripheral projections. This activity required both electrical and chemical transmission, and acetylcholine, rather than glutamate, provided the main excitatory drive. Our data are consistent with motoneurons themselves playing a critical role in generating such activity by making excitatory connections on each other and on GABAergic interneurons via dihydro-beta-erythroidine hydrobromide (DHbetaE)-insensitive nicotinic receptors. This resulted in the generation of local bursts. Consistent with these observations, E12-E12.5 mouse motoneurons retrogradely labeled by HRP were observed to have extensive axon collaterals that projected locally within the lateral motor column and to interneuron-containing regions dorsal and medial of the lateral motor column. Cholinergic axons, presumably from motoneurons, were also observed in the ventral and lateral funiculi. However, for local bursts to propagate throughout the cord, a second DHbetaE-sensitive cholinergic pathway that also involved glycinergic interneurons was required. This circuit characterization should facilitate the use of genetic mutations that alter specific subpopulations of interneurons or cholinergic transmission to determine how modifying different aspects of this early activity affects subsequent development of the spinal motor circuit.
Indexed as
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12533619PMC6741864W1632057558What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.