ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
A novel skilled-reaching impairment in paw supination on the "good" side of the hemi-Parkinson rat improved with rehabilitation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 74 citations in OpenAlex.
- Automated system for training and assessing reaching and grasping behaviors in rodents.Journal of neuroscience methods · 2024Article
- Longitudinal assessment of skilled forelimb motor impairments in DJ-1 knockout rats.Behavioural brain research · 2022Article
- Cortico-striatal circuits for bilaterally coordinated movements.Science advances · 2022Article
- Altered Recruitment of Motor Cortex Neuronal Activity During the Grasping Phase of Skilled Reaching in a Chronic Rat Model of Unilateral Parkinsonism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Effects of Electric Cortical Stimulation (ECS) and Transcranial Direct Current Stimulation (tDCS) on Rats With a Traumatic Brain Injury.Annals of rehabilitation medicine · 2018Article
- An automated rat single pellet reaching system with high-speed video capture.Journal of neuroscience methods · 2016Article
- The supination assessment task: An automated method for quantifying forelimb rotational function in rats.Journal of neuroscience methods · 2016Article
- The neostriatum: two entities, one structure?Brain structure & function · 2016Article
- Effect of Epidural Electrical Stimulation and Repetitive Transcranial Magnetic Stimulation in Rats With Diffuse Traumatic Brain Injury.Annals of rehabilitation medicine · 2015Article
- An automated behavioral box to assess forelimb function in rats.Journal of neuroscience methods · 2015Article
- Motor Skill Learning Is Associated with Phase-Dependent Modifications in the Striatal cAMP/PKA/DARPP-32 Signaling Pathway in Rodents.PloS one · 2015Article
- Bilateral Synergy: A Framework for Post-Stroke Rehabilitation.Journal of neurology & translational neuroscience · 2013Article
- The effect of continuous epidural electrical stimulation on neuronal proliferation in cerebral ischemic rats.Annals of rehabilitation medicine · 2013Article
- SPARC regulates microgliosis and functional recovery following cortical ischemia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- The effect of electric cortical stimulation after focal traumatic brain injury in rats.Annals of rehabilitation medicine · 2012Article
- Female CGG knock-in mice modeling the fragile X premutation are impaired on a skilled forelimb reaching task.Neurobiology of learning and memory · 2012Article
- Progressive motor cortex functional reorganization following 6-hydroxydopamine lesioning in rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Deficits in fine motor skills in a genetic animal model of ADHD.Behavioral and brain functions : BBF · 2010Article
- Nerve-Injury Induced Changes to GluR1 and GluR2/3 Sub-unit Expression in Area 3b of Adult Squirrel Monkeys: Developmental Recapitulation?Frontiers in systems neuroscience · 2009Article
- Enhanced function in the good forelimb of hemi-parkinson rats: compensatory adaptation for contralateral postural instability?Experimental neurology · 2008Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parkinson's disease is characterized by tremor, rigidity, bradykinesia, and postural abnormalities ascribed to the loss of nigrostriatal dopamine (DA). Symptoms similar to the human condition can be produced in the rat by DA-depleting 6-hydroxydopamine injections made into the nigrostriatal system. After a unilateral lesion, the rat symptoms include sensory and motor impairments and turning biases reflecting motor abnormalities to the contralateral-to-depletion side of the body. In addition, a number of studies on skilled reaching report impairments in the use of the ipsilateral limb. It is suggested that the ipsilateral deficit is secondary to the contralateral motor impairments however. Here we re-examine how rats with unilateral DA depletion use their ipsilateral limb for skilled reaching for food. We provide the first description of an impairment on the ipsilateral-to-depletion side of the body of the rat and the first demonstration of amelioration of the defect using behavioral therapy. Video analysis of rats reaching for single pellets of food with the ipsilateral limb revealed that, although limb advancement and food grasping were normal, paw supination and food release to the mouth were impaired. Consequently, the animals were unable to transport a grasped food pellet to the mouth. Behavioral therapy, consisting of training in a simpler reaching task, strikingly lessened the impairment and improved reaching movements to the point that the rats could transport the food to the mouth. The results are discussed in relation to possible causes of the ipsilateral impairment, its treatment, and to relevant research on human Parkinson patients, indicating that they display bilateral improvements after unilateral treatments.
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Identifiers
12533618PMC6741884W2168796299What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.