ArticleWorld journal of gastroenterology2003
Relationship between expression of E-cadherin-catenin complex and clinicopathologic characteristics of pancreatic cancer.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Prognostic and Clinicopathological Significance of E-Cadherin in Pancreatic Cancer Patients: A Meta-Analysis.Frontiers in oncology · 2021Pooled it
- Article
- Article
- Cadherin Signaling in Cancer and Autoimmune Diseases.International journal of molecular sciences · 2021Review
- Review
- MicroRNA co-expression networks exhibit increased complexity in pancreatic ductal compared to Vater's papilla adenocarcinoma.Oncotarget · 2017Article
- Subclinical Inflammation and Endothelial Dysfunction in Patients with Chronic Pancreatitis and Newly Diagnosed Pancreatic Cancer.Digestive diseases and sciences · 2016Article
- Loss of E-cadherin expression and outcome among patients with resectable pancreatic adenocarcinomas.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2011Article
- Pancreatic ductal adenocarcinoma and transcription factors: role of c-Myc.Journal of gastrointestinal cancer · 2011Review
- Molecular characteristics of pancreatic ductal adenocarcinoma.Pathology research international · 2011Article
- Prognostic relevance of β-catenin expression in T2-3N0M0 esophageal squamous cell carcinoma.World journal of gastroenterology · 2010Article
- E-cadherin expression pattern in primary colorectal carcinomas and their metastases reflects disease outcome.World journal of gastroenterology · 2006Article
- DNA ploidy analysis and expression of MMP-9, TIMP-2, and E-cadherin in gastric carcinoma.World journal of gastroenterology · 2005Article
- Beta-catenin up-regulates the expression of cyclinD1, c-myc and MMP-7 in human pancreatic cancer: relationships with carcinogenesis and metastasis.World journal of gastroenterology · 2005Article
- Osteopontin expression in ductal adenocarcinomas and undifferentiated carcinomas of the pancreas.Virchows Archiv : an international journal of pathology · 2005Article
- CDH1 germline mutation in hereditary gastric carcinoma.World journal of gastroenterology · 2004Review
- Effects of daidzein on estrogen-receptor-positive and negative pancreatic cancer cells in vitro.World journal of gastroenterology · 2004Article
- Relationship between nuclear morphometry, DNA content and resectability of pancreatic cancer.World journal of gastroenterology · 2003Article
- Can Molecular Biomarkers Change the Paradigm of Pancreatic Cancer Prognosis?BioMed research internationalReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the expression of E-cadherin and alpha-catenin and beta-catenin in pancreatic carcinoma and its relationship with the clinicopathologic characteristics, and clarify the mechanism of invasion and metastasis of pancreatic cancer.
methodsThe expression of E-cadherin and alpha-, beta-catenin was examined in 47 cases of infiltrative ductal adenocarcinoma of pancreas and 12 adult normal pancreatic tissues by immunohistochemical technique.
resultsThe immunoreactivity of E-cadherin and alpha-, beta-catenin was expressed by normal ductal and acinar cells with strong membranous staining at the intercellular border in 12 cases of adult normal pancreatic tissues. Abnormal expression of E-cadherin and alpha-, beta-catenin in 47 pancreatic carcinoma tissues was demonstrated in 53.2 %, 61.7 % and 68.1 %, respectively. Both abnormal expression of E-cadherin and alpha-catenin significantly correlated with differentiation, lymph node and liver metastases (P<0.05, respectively), whereas aberrant beta-catenin expression only correlated with lymph node and liver metastases (P<0.001). Abnormal E-cadherin and alpha-, beta-catenin expression was not associated with tumor size, invasion and survival time of patients (P>0.05, all).
conclusionPancreatic cancer likely occurs in case of E-cadherin-catenin complex genes mutations or deletions and abnormal expression of proteins, which significantly correlate with the biologic character of the tumor and lymph node and liver metastases. It is suggested that the abnormal E-cadherin-catenin complex expression plays an important role in the development and progression of tumor, and thus may become a new marker in pancreatic cancer metastasis.
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