ArticleWorld journal of gastroenterology2003
Effect of leflunomide on immunological liver injury in mice.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Leflunomide an immunomodulator with antineoplastic and antiviral potentials but drug-induced liver injury: A comprehensive review.International immunopharmacology · 2021Review
- Anti-inflammatory and Anti-arthritic Effects of a Novel Leflunomide Analogue, UTL-5b (GBL-5b).American journal of biomedical sciences · 2011Article
- Effect of leflunomide on liver regeneration after partial hepatectomy in rats.Pediatric surgery international · 2010Article
- Protective effects of leflunomide on intestinal ischemia-reperfusion injury: leflunomide against intestinal ischemia-reperfusion.Digestive diseases and sciences · 2010Article
- Role of alpha-actin in muscle damage of injured athletes in comparison with traditional markers.British journal of sports medicine · 2007Article
- Hepatic damage in biliary-obstructed rats is ameliorated by leflunomide treatment.Pediatric surgery international · 2006Article
- Protective effects of leflunomide against ischemia-reperfusion injury of the rat liver.Pediatric surgery international · 2006Article
- Gastroprotective effect and mechanism of amtolmetin guacyl in mice.World journal of gastroenterology · 2004Article
- Effects of 24 h ultra-marathon on biochemical and hematological parameters.World journal of gastroenterology · 2004Article
- Protective effect of melatonin against liver injury in mice induced by Bacillus Calmette-Guerin plus lipopolysaccharide.World journal of gastroenterology · 2004Article
- Leflunomide attenuates hepatocyte injury by inhibiting Kupffer cells.World journal of gastroenterology · 2004Article
- A 771726, the active metabolite of leflunomide, inhibits TNF-alpha and IL-1 from Kupffer cells.Inflammation · 2004Article
- Ginkgo biloba extract reverses CCl4-induced liver fibrosis in rats.World journal of gastroenterology · 2004Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the effect of leflunomide on immunological liver injury (ILI) in mice.
methodsILI was induced by tail vein injection of 2.5 mg Bacillus Calmette-Guerin (BCG), and 10 d later with 10 microg lipopolysaccharide (LPS) in 0.2 mL saline (BCG+LPS). The alanine aminotransferase (ALT), aspartate aminotransferase (AST), nitric oxide (NO) level in plasma and molondiadehyde (MDA), glutathione peroxidase (GSHpx) in liver homogenate were assayed by spectroscopy. The serum content of tumor necrosis factors-alpha (TNF-alpha) was determined by ELISA. Interleukin-1 (IL-1), interleukin-2 (IL-2) and Concanavalin A (ConA)-induced splenocyte proliferation response were determined by methods of (3)H-infiltrated cell proliferation.
resultsLeflunomide (4, 12, 36 mg.kg(-1)) was found to significantly decrease the serum transaminase (ALT, AST) activity and MDA content in liver homogenate, and improve reduced GSHpx level of liver homogenate. Leflunomide (4, 12, 36 mg.kg(-1)) significantly lowered TNF-alpha and NO level in serum, and IL-1 produced by intraperitoneal macrophages(PMphi). Moreover, the decreased IL-2 production and ConA-induced splenocyte proliferation response were further inhibited.
conclusionThese findings suggested that leflunomide had significant protective action on ILI in mice.
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