ArticleWorld journal of gastroenterology2003
Clinical characteristics and diagnosis of patients with hereditary nonpolyposis colorectal cancer.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 44 citations in OpenAlex.
- Cost-Utility Analysis of Universal Lynch Syndrome Screening among Colorectal Cancer Patients in a Low-Middle-Income Country.Yonsei medical journal · 2025Article
- Profiling of the genetic features of Chinese patients with gastric cancer with HRD germline mutations in a large-scale retrospective study.Journal of medical genetics · 2023Article
- Negative to positive lymph node ratio is a superior predictor than traditional lymph node status in stage III colorectal cancer.Oncotarget · 2016Article
- Familial Gastric Cancers.The oncologist · 2015Review
- Clinicopathological and genetic features of Chinese hereditary nonpolyposis colorectal cancer (HNPCC).Medical oncology (Northwood, London, England) · 2014Article
- Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion.Molecular cancer · 2013Article
- Hereditary nonpolyposis colorectal cancer and familial colorectal cancer in Central part of Iran, Isfahan.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2012Article
- Gastric tumours in hereditary cancer syndromes: clinical features, molecular biology and strategies for prevention.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2011Review
- Molecular analysis: microsatellity instability and loss of heterozygosity of tumor suppressor gene in hereditary non-polyposis colorectal cancers (HNPCC).Bosnian journal of basic medical sciences · 2009Article
- Hereditary colorectal cancer in china.Hereditary cancer in clinical practice · 2005Article
- Clinicopathological and molecular genetic analysis of HNPCC in China.World journal of gastroenterology · 2005Article
- Hereditary nonpolyposis colorectal cancer (Lynch syndrome): criteria for identification and management.Digestive diseases and sciences · 2005Review
- The tumor spectrum in the Lynch syndrome.Familial cancer · 2005Review
- Genetic detection of Chinese hereditary nonpolyposis colorectal cancer.World journal of gastroenterology · 2004Article
- Comparative evaluation of immune response after laparoscopical and open total mesorectal excisions with anal sphincter preservation in patients with rectal cancer.World journal of gastroenterology · 2003Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the clinical characteristics of hereditary nonpolyposis colorectal cancer (HNPCC) in the Chinese population and discuss the identification and management of the patients with HNPCC.
methodsA series of 140 patients with colorectal cancers (CRC) and HNPCC associated tumors from 30 families fulfilling the Amsterdam criteria were analyzed.
resultsA total of 118 patients had CRC. Average age at diagnosis of the first CRC was 45.7 years, 56.8 % and 23.4 % of the first CRC were located proximal to the splenic flexure and in the rectum respectively. Twenty-three (19.5 %) had synchronous and metachronous CRC. Twenty-seven patients were found to have extracolonic tumors. Gastric carcinoma was the most common tumor type in our series (44.4 %).
conclusionThe frequency of HNPCC was 2.6 % in our series of patients. The main features are an excess of early onset with a propensity to involve the proximal colon, and high frequency of multiple foci. Management and surveillance for these patients should be different from sporadic CRC. Contrary to American and European reports, gastric cancer seems more frequent than endometrial cancer in Chinese. It is necessary to formulate a new HNPCC criterion for Chinese patients.
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