ArticleWorld journal of gastroenterology2003
Expression of 1A6 gene and its correlation with intestinal gastric carcinoma.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 6 citations in OpenAlex.
- Giant malignant gastrointestinal stromal tumors: recurrence and effects of treatment with STI-571.World journal of gastroenterology · 2005Article
- Endoscopic patterns of gastric mucosa and its clinicopathological significance.World journal of gastroenterology · 2003Article
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5 authors at 1 institution in 1 country.
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Abstract
aimTo investigate the expression of 1A6 gene in the lesions during the development of intestinal gastric carcinoma.
methodsOne hundred and thirty-six cases of intestinal metaplasia (IM) from surgical resections and biopsy were classified by mucous staining. Expression of 1A6 in all cases was detected using immunohistochemical S-P method.
resultsThe positive rates of 1A6 in normal and superficial gastritis (SG), severe atrophic gastritis (SAG), type I, II, III IM, dysplasia (Dys) and intestinal gastric carcinoma (IGC) were 12.2 %, 16.7 %, 7.1 %, 22.6 %, 47.8 %, 46.9 % and 60.8 %, respectively. A significant difference among type III IM and SG, SAG, type I and II IM was found (P<0.01), the difference between type III and Dys, IGC being not significant.
conclusionAs a new tumor-related gene, expression of 1A6 may be an effective parameter to predict the malignant transformation of precancerous lesion to gastric carcinoma.
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