ReviewWorld journal of gastroenterology2003
Hepatic stem cells: existence and origin.
Review in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Stem Cells in Regenerative Medicine: A Journey from Adult Stem Cells to Induced Pluripotent Cells.International journal of molecular sciences · 2025Review
- From Cells to Exosomes: a Review of Non-Surgical Biotherapeutic-Based Strategies for Liver Regeneration in the Face of End-Stage Diseases.Stem cell reviews and reports · 2025Review
- Stem Cell Therapy in Dengue Virus-Infected BALB/C Mice Improves Hepatic Injury.Frontiers in cell and developmental biology · 2021Article
- Mechanisms of hepatocellular carcinoma progression.World journal of gastroenterology · 2019Review
- The Selection of a Hepatocyte Cell Line Susceptible toFrontiers in microbiology · 2019Article
- Cellular Mechanisms of Liver Regeneration and Cell-Based Therapies of Liver Diseases.BioMed research international · 2017Review
- Hepatic Differentiation of Human Induced Pluripotent Stem Cells in a Perfused Three-Dimensional Multicompartment Bioreactor.BioResearch open access · 2016Article
- Human hepatic progenitor cells express hematopoietic cell markers CD45 and CD109.International journal of medical sciences · 2014Article
- In situ tissue regeneration through host stem cell recruitment.Experimental & molecular medicine · 2013Review
- Embryonic stem cells develop into hepatocytes after intrasplenic transplantation in CCl4-treated mice.World journal of gastroenterology · 2007Article
- Engineering complex tissues.Tissue engineering · 2006Review
- Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells.World journal of gastroenterology · 2006Article
- An in vitro study of hematopoietic progenitor cells from peripheral blood of rabbits.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2005Article
- Adult stem cells and cancer stem cells: tie in or tear apart?Journal of cancer research and clinical oncology · 2005Review
- Effect of stem cell mobilization with cyclophosphamide plus granulocyte colony-stimulating factor on morphology of haematopoietic organs in mice.Cell proliferation · 2005Article
- Selection, proliferation and differentiation of bone marrow-derived liver stem cells with a culture system containing cholestatic serum in vitro.World journal of gastroenterology · 2004Article
- Possible stem cell origin of human cholangiocarcinoma.World journal of gastroenterology · 2004Article
- Hepatic differentiation capability of rat bone marrow-derived mesenchymal stem cells and hematopoietic stem cells.World journal of gastroenterology · 2004Article
- Hepatic progenitor cells in human liver cirrhosis: immunohistochemical, electron microscopic and immunofluorencence confocal microscopic findings.World journal of gastroenterology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stem cells are not only units of biological organization, responsible for the development and the regeneration of tissue and organ systems, but also are units in evolution by natural selection. It is accepted that there is stem cell potential in the liver. Like most organs in a healthy adult, the liver maintains a perfect balance between cell gain and loss. It has three levels of cells that can respond to loss of hepatocytes: (1) Mature hepatocytes, which proliferate after normal liver tissue renewal, less severe liver damage, etc; they are numerous, unipotent, "committed" and respond rapidly to liver injury. (2) Oval cells, which are activated to proliferate when the liver damage is extensive and chronic, or if proliferation of hepatocytes is inhibited; they lie within or immediately adjacent to the canal of Hering (CoH); they are less numerous, bipotent and respond by longer, but still limited proliferation. (3) Exogenous liver stem cells, which may derive from circulating hematopoietic stem cells (HSCs) or bone marrow stem cells; they respond to allyl alcohol injury or hepatocarcinogenesis; they are multipotent, rare, but have a very long proliferation potential. They make a more significant contribution to regeneration, and even completely restore normal function in a murine model of hereditary tyrosinaemia. How these three stem cell populations integrate to achieve a homeostatic balance remains enigmatic. This review focuses on the location, activation, markers of the three candidates of liver stem cell, and the most importantly, therapeutic potential of hepatic stem cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.