ArticleThe Journal of allergy and clinical immunology2003
Rhinovirus-induced wheezing in infancy--the first sign of childhood asthma?
Article in The Journal of allergy and clinical immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 173 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
173 citing papers in PubMed, 4 syntheses or guidelines pooled it, 401 citations in OpenAlex.
- Prevalence of respiratory viruses using polymerase chain reaction in children with wheezing, a systematic review and meta-analysis.PloS one · 2020Pooled it
- Association between rhinovirus wheezing illness and the development of childhood asthma: a meta-analysis.BMJ open · 2017Pooled it
- Pooled it
- Diagnosis of asthma.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2005Guideline
- Prednisolone reduces recurrent wheezing after first rhinovirus wheeze: a 7-year follow-up.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2013Trial
- Allergic sensitization is associated with rhinovirus-, but not other virus-, induced wheezing in children.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2010Trial
- Atopic characteristics of wheezing children and responses to prednisolone.Pediatric pulmonology · 2007Trial
- Efficacy of prednisolone in children hospitalized for recurrent wheezing.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2007Trial
- Prednisolone reduces recurrent wheezing after a first wheezing episode associated with rhinovirus infection or eczema.The Journal of allergy and clinical immunology · 2007Trial
- Rhinovirus Species in Acute Respiratory Tract Infections and the Risk of Asthma in Children.Pediatric pulmonology · 2026Article
- Evidence-based guideline for clinical practice in the diagnosis, treatment, management, and prevention of recurrent wheezing in infants and toddlers in China.Pediatric investigation · 2026Article
- Article
- The association between COVID-19 vaccine/infection and new-onset asthma in children - based on the global TriNetX database.Infection · 2025Article
- Identification and Analysis of Type 2 Innate Lymphoid Cells in Rhinovirus-Infected Mouse Model of Asthma.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Infection of Immature Mice with Rhinovirus for the Study of Asthma Pathogenesis.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Cord blood granulocyte levels are associated with severe bronchiolitis in the first year of life.Clinical & translational immunology · 2024Article
- Dynamic Patterns and Predominance of Respiratory Pathogens Post-COVID-19: Insights from a Two-Year Analysis.Journal of epidemiology and global health · 2024Article
- Old foes following news ways?-Pandemic-related changes in the epidemiology of viral respiratory tract infections.Infection · 2024Article
- Article
- Interferons as negative regulators of ILC2s in allergic lung inflammation and respiratory viral infections.Journal of molecular medicine (Berlin, Germany) · 2023Review
113 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough known as common causes of upper respiratory infections, rhinoviruses, enteroviruses, and corona-viruses are poorly studied as inducers of wheezing in infants, and their possible role in the development of childhood asthma has not been investigated.
objectiveThe purposes of this study were to assess the occurrence of RV, enterovirus, and coronavirus infections in wheezing infants and to evaluate the association of these viral findings with early school-age asthma.
methodsIn 1999, outcome in relation to asthma was studied in 82 of 100 initially recruited children who had been hospitalized for wheezing in infancy during the period 1992-1993. In 2000, etiologic viral studies regarding the index episode of wheezing were supplemented by rhinovirus, enterovirus, and coronavirus detection by RT-PCR from frozen nasopharyngeal aspirates in 81 of the children for whom adequate samples were available. Of these children, 66 had participated in the follow-up in 1999.
resultsRhinoviruses were identified in 27 (33%) of the 81 children, enteroviruses in 10 (12%), and coronaviruses in none. Rhinoviruses were present as single viral findings in 22 (81%) of the 27 rhinovirus-positive cases, and rhinovirus infections were associated with the presence of atopic dermatitis in infancy. Enteroviruses were commonly encountered in mixed infections and had no association with atopy. As single viral findings, rhinoviruses were associated with the development of asthma (P =.047; odds ratio, 4.14; 95% CI, 1.02-16.77 versus rhinovirus-negative cases [by logistic regression adjusted for age, sex, and atopic dermatitis on entry)].
conclusionOur results present rhinoviruses as important inducers of wheezing even in infancy. The association with atopy and subsequent asthma calls for reevaluation of the role of rhinoviruses in the development of asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.