Evidence map›Paper›PMID 12530934›Full record

ReviewCurrent hypertension reports2003

Linkage disequilibrium analysis of the renin-angiotensin system genes.

Xiaofeng Zhu, Richard S Cooper

2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Current hypertension reports, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00005340 completednot on this map

Hypertension in Blacks of West African Origin

TypeobservationalSponsorNational Heart, Lung, and Blood Institute (NHLBI)Ran1991 to 2005ConditionsCardiovascular Diseases, Heart Diseases, Hypertension, Obesity
NCT00037271 completednot on this map

Genome Scan for Obesity in a Multi-Ethnic Sample

TypeobservationalSponsorNational Heart, Lung, and Blood Institute (NHLBI)Ran2001 to 2003ConditionsCardiovascular Diseases, Heart Diseases, Obesity
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Xiaofeng ZhuDepartment of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, 2160 S. First Ave, Maywood, IL 60153, USA. xzhu1@lumc.edu
Richard S Cooper

Funding

HYPERTENSION IN POPULATIONS OF WEST AFRICAN ORIGINR37HL045508 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI COOPER, RICHARD STANLEY · 1998 to 2008
$3.3M
Genome Scan for Obesity in a Multi-Ethnic SampleR03HL065702 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI ZHU, XIAOFENG · 2001 to 2002
$148k
HYPERTENSION IN POPULATIONS OF WEST AFRICAN ORIGINR01HL045508 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI COOPER, RICHARD STANLEY · 1991 to 1998
–
NHLBI NIH HHS HL 45508NHLBI NIH HHS HL65702
6 · The paper itself

Abstract

The genes of the renin-angiotensin system (RAS) are important candidates to confer susceptibility to cardiovascular diseases. A large number of association studies between cardiovascular traits and the polymorphisms in RAS have been conducted, although inconsistent results are often reported. The patterns of linkage disequilibrium in RAS genes have also been reported in different populations. However, our understanding of the genetic architecture underlying the RAS is still limited despite rapid progress in empiric studies regarding the patterns of the human genome as a whole. In this review, the linkage disequilibrium among the polymorphisms within the four RAS genes and current association analyses involving the RAS are discussed, as well as some of the gaps of knowledge and possible solutions.

Indexed as

Linkage DisequilibriumCardiovascular DiseasesGene FrequencyHaplotypesHumansHypertensionPolymorphism, GeneticRenin-Angiotensin System

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.