ArticleEuropean journal of epidemiology2001
Validation of general practitioner-diagnosed COPD in the UK General Practice Research Database.
Article in European journal of epidemiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Validity of diagnostic coding within the General Practice Research Database: a systematic review.The British journal of general practice : the journal of the Royal College of General Practitioners · 2010Pooled it
- Validation and validity of diagnoses in the General Practice Research Database: a systematic review.British journal of clinical pharmacology · 2010Pooled it
- Markers of exacerbation severity in chronic obstructive pulmonary disease.Respiratory research · 2006Pooled it
- No Evidence of Off-label Use of Olodaterol and Indacaterol in Denmark, France, and the Netherlands: A Drug Utilization Study.Scientific reports · 2020Article
- Development and Validation of an Algorithm to Accurately Identify Atopic Eczema Patients in Primary Care Electronic Health Records from the UK.The Journal of investigative dermatology · 2017Article
- Identifying individuals with physician-diagnosed chronic obstructive pulmonary disease in primary care electronic medical records: a retrospective chart abstraction study.NPJ primary care respiratory medicine · 2017Article
- Validity and interpretation of spirometric recordings to diagnose COPD in UK primary care.International journal of chronic obstructive pulmonary disease · 2017Article
- Development and validation of method for defining conditions using Chinese electronic medical record.BMC medical informatics and decision making · 2016Article
- How Reliable Are Current Data for Assessing the Actual Prevalence of Chronic Obstructive Pulmonary Disease?PloS one · 2016Article
- Validation of chronic obstructive pulmonary disease recording in the Clinical Practice Research Datalink (CPRD-GOLD).BMJ open · 2014Article
- Validating the 8 CPCSSN case definitions for chronic disease surveillance in a primary care database of electronic health records.Annals of family medicine · 2014Article
- Article
- Prevalence and burden of breathlessness in patients with chronic obstructive pulmonary disease managed in primary care.PloS one · 2014Article
- A pathway to improved prospective observational post-authorization safety studies.Drug safety · 2012Review
- Reassessing the evidence hierarchy in asthma: evaluating comparative effectiveness.Current allergy and asthma reports · 2011Review
- Long-term use of fluticasone propionate/salmeterol fixed-dose combination and incidence of cataracts and glaucoma among chronic obstructive pulmonary disease patients in the UK General Practice Research Database.International journal of chronic obstructive pulmonary disease · 2011Article
- Adjusting for COPD severity in database research: developing and validating an algorithm.International journal of chronic obstructive pulmonary disease · 2011Article
- Effectiveness of inhaler types for real-world asthma management: retrospective observational study using the GPRD.Journal of asthma and allergy · 2011Article
- Thromboembolic events among adult patients with primary immune thrombocytopenia in the United Kingdom General Practice Research Database.Haematologica · 2010Article
- Chronic obstructive pulmonary disease and the risk of cardiovascular diseases.European journal of epidemiology · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInformation in large, automated databases can be useful to study the natural history of respiratory diseases in the community, but the validity of definitions needs to be demonstrated.
aimTo compare a simple computer algorithm that identifies patients diagnosed with chronic obstructive pulmonary disease (COPD) and severity of COPD in the UK General Practice Research Database (GPRD) with general practitioner (GP) clinical records, to evaluate the utility of this algorithm for identifying COPD patients and for distinguishing COPD from asthma.
methodsUsing a computer algorithm identifying patients by diagnostic codes and allotting three grades of severity by drug use, a sample of 225 patients in the GPRD with a diagnosis of COPD and an age-sex matched group of 75 patients with asthma were randomly selected. Questionnaires were posted to the GPs of the 300 selected patients who were asked to state diagnosis and to grade severity based on the individual's medical record. Agreement was quantified with the kappa index, an estimator that accounts for agreement that occurs by chance.
resultsResponse rate was 85.7%. The concordance between COPD diagnosis by the GPRD algorithm with that of the GP was quantified as a kappa of 0.52, and the concordance between COPD severity by the GPRD algorithm with that of the GP was quantified as a kappa of 0.54. The kappa index for COPD diagnosis increased with increasing severity of COPD (0.46, 0.59, and 0.68 for mild, moderate and severe COPD, respectively), but similar good agreement was observed in a stratified analysis by sex, age, smoking status and number of comorbidities.
conclusionsIt is concluded that the GPRD algorithms used for diagnosis and severity of COPD are a good screening tool for COPD in the UK general population, and satisfactorily differentiate COPD from asthma patients, particularly when disease is moderate or severe.
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