ArticlePlant physiology2003
Alanine aminotransferase homologs catalyze the glutamate:glyoxylate aminotransferase reaction in peroxisomes of Arabidopsis.
Article in Plant physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed, 175 citations in OpenAlex.
- The C2H2-GGAT Regulatory Module Fine-Tunes Glutamate Homeostasis to Improve Fruit Flavour and Enhance Disease Resistance in Peach.Plant biotechnology journal · 2026Article
- Integrated transcriptomic and metabolomic analyses reveal biphasic thermal adaptation strategies inPeerJ · 2026Article
- Mapping multi-substrate specificity of Arabidopsis aminotransferases.Nature plants · 2025Article
- A cytosolic glyoxylate shunt complements the canonical photorespiratory pathway in Arabidopsis.Nature communications · 2025Article
- The homeostasis of β-alanine is key for Arabidopsis reproductive growth and development.The Plant journal : for cell and molecular biology · 2025Article
- Role of alanine aminotransferase in crop resilience to climate change: a critical review.Physiology and molecular biology of plants : an international journal of functional plant biology · 2024Review
- Synthesis of β-Alanine From Isoleucine and Propionate Catabolism via Aminotransferases.Plant direct · 2024Article
- Rubisco activity and activation state dictate photorespiratory plasticity in Betula papyrifera acclimated to future climate conditions.Scientific reports · 2024Article
- Removal of phosphoglycolate in hyperthermophilic archaea.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Spectrophotometric Assays for Measuring Photorespiratory Glutamate:Glyoxylate and Serine:Glyoxylate Aminotransferase Reactions.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Growth in fluctuating light buffers plants against photorespiratory perturbations.Nature communications · 2023Article
- Salt Stress-Related Mechanisms in Leaves of the Wild BarleyLife (Basel, Switzerland) · 2023Article
- The diversity of substrates for plant respiration and how to optimize their use.Plant physiology · 2023Review
- Integrating multiomics data accelerates elucidation of plant primary and secondary metabolic pathways.aBIOTECH · 2023Review
- Article
- Genetic mapping of QTLs controlling brown seed coat traits by genome resequencing in sesame (Frontiers in plant science · 2023Article
- The Impact of Photorespiratory Glycolate Oxidase Activity onMetabolites · 2021Article
- Secretome Analysis ofInternational journal of molecular sciences · 2021Article
- Phosphomimetic T335D Mutation of Hydroxypyruvate Reductase 1 Modifies Cofactor Specificity and Impacts Arabidopsis Growth in Air.Plant physiology · 2020Article
- The low-copy nuclear gene Agt1 as a novel DNA barcoding marker for Bromeliaceae.BMC plant biology · 2020Article
6 more citing papers are in PubMed but not listed here.
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2 authors at 1 institution in 1 country.
Funding
Abstract
Plant peroxisomal glyoxylate aminotransferases play central roles within the photorespiratory pathway. Genes encoding glyoxylate aminotransferases have been isolated from several animals and microbes, but only recently have plant homologs been identified. Three Arabidopsis homologs of alanine (Ala):glyoxylate aminotransferase 2 (AGT2) contain a putative type 1 peroxisomal targeting signal (PTS1), but the metabolic significance of these AGT2 homologs is unknown. GGT1 and GGT2 are Ala aminotransferase (AlaAT) homologs from Arabidopsis that represent another type of glyoxylate aminotransferase. These proteins are class I aminotransferases, each containing a putative PTS1. GGT1 and GGT2 are members of a small family of AlaATs in Arabidopsis. When expressed as recombinant proteins in Escherichia coli, GGT1 and GGT2 displayed biochemical characteristics very similar to one another, and to the Arabidopsis protein purified from leaves. Four aminotransferase activities were specifically associated with GGT1 and GGT2, using the substrate pairs glutamate (Glu):glyoxylate, Ala:glyoxylate, Glu:pyruvate, and Ala:2-oxoglutarate. GGT1 and GGT2 may have partially redundant functions; transcripts of both genes were detected in many of the same tissues. Although Glu:glyoxylate aminotransferase (GGT) activity has been observed in several locations in different plants and algae, including the cytoplasm and mitochondria, our subcellular fractionation data indicate that GGT activity was exclusively peroxisomal in Arabidopsis. Thus, glyoxylate aminotransferase reactions in plant peroxisomes appear to be catalyzed by at least two distinct types of aminotransferases: an AGT1 homolog with serine:glyoxylate aminotransferase activity (A.H. Liepman, L.J. Olsen [2001] Plant J 25: 487-498), and a pair of closely related, potentially redundant AlaAT homologs with GGT activity.
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