ArticleMolecular biology of the cell2003
Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap.
Article in Molecular biology of the cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
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- Disease-Associated Mutant Tau Prevents Circadian Changes in the Cytoskeleton of Central Pacemaker Neurons.Frontiers in neuroscience · 2020Article
- ER responses play a key role in Swiss-Cheese/Neuropathy Target Esterase-associated neurodegeneration.Neurobiology of disease · 2019Article
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- Using Drosophila Models and Tools to Understand the Mechanisms of Novel Human Cancer Driver Gene Function.Advances in experimental medicine and biology · 2019Review
- Disease-Associated PNPLA6 Mutations Maintain Partial Functions When Analyzed inFrontiers in neuroscience · 2019Article
- Control of basal autophagy rate by vacuolar peduncle.PloS one · 2019Article
- LIN-3/EGF promotes the programmed cell death of specific cells in Caenorhabditis elegans by transcriptional activation of the pro-apoptotic gene egl-1.PLoS genetics · 2014Article
- Regulation of branching dynamics by axon-intrinsic asymmetries in Tyrosine Kinase Receptor signaling.eLife · 2014Article
- Neurofibromin mediates FAK signaling in confining synapse growth at Drosophila neuromuscular junctions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Amyloid precursor proteins are protective in Drosophila models of progressive neurodegeneration.Neurobiology of disease · 2012Article
- Probing mechanisms that underlie human neurodegenerative diseases in Drosophila.Annual review of genetics · 2012Review
- Swiss cheese et allii, some of the first neurodegenerative mutants isolated in Drosophila.Journal of neurogenetics · 2009Review
- Article
- Accelerated accumulation of misfolded prion protein and spongiform degeneration in a Drosophila model of Gerstmann-Sträussler-Scheinker syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Neurodegenerative mutants in Drosophila: a means to identify genes and mechanisms involved in human diseases?Invertebrate neuroscience : IN · 2005Review
- p120 Ras GTPase-activating protein associates with fibroblast growth factor receptors in Drosophila.The Biochemical journal · 2004Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Ras signaling has been shown to play an important role in promoting cell survival in many different tissues. Here we show that upregulation of Ras activity in adult Drosophila neurons induces neuronal cell death, as evident from the phenotype of vacuolar peduncle (vap) mutants defective in the Drosophila RasGAP gene, which encodes a Ras GTPase-activating protein. These mutants show age-related brain degeneration that is dependent on activation of the EGF receptor signaling pathway in adult neurons, leading to autophagic cell death (cell death type 2). These results provide the first evidence for a requirement of Egf receptor activity in differentiated adult Drosophila neurons and show that a delicate balance of Ras activity is essential for the survival of adult neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.