ArticleMolecular biology of the cell2003
The protein tyrosine phosphatase PTP-BL associates with the midbody and is involved in the regulation of cytokinesis.
Article in Molecular biology of the cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- The SH2 domain and kinase activity of JAK2 target JAK2 to centrosome and regulate cell growth and centrosome amplification.PloS one · 2022Article
- Dual Role of the PTPN13 Tyrosine Phosphatase in Cancer.Biomolecules · 2020Review
- TheFrontiers in microbiology · 2020Article
- PTPN13 induces cell junction stabilization and inhibits mammary tumor invasiveness.Theranostics · 2020Article
- The binding affinity of PTPN13's tandem PDZ2/3 domain is allosterically modulated.BMC molecular and cell biology · 2019Article
- Article
- Proteomic Analysis of NCK1/2 Adaptors Uncovers Paralog-specific Interactions That Reveal a New Role for NCK2 in Cell Abscission During Cytokinesis.Molecular & cellular proteomics : MCP · 2018Article
- Proteinaceous Regulators and Inhibitors of Protein Tyrosine Phosphatases.Molecules (Basel, Switzerland) · 2018Review
- EphrinB1: novel microtubule associated protein whose expression affects taxane sensitivity.Oncotarget · 2015Article
- JAK2 tyrosine kinase phosphorylates and is negatively regulated by centrosomal protein Ninein.Molecular and cellular biology · 2015Article
- Article
- Valosin containing protein (VCP/p97) is a novel substrate for the protein tyrosine phosphatase PTPL1.Experimental cell research · 2013Article
- Downregulation of protein tyrosine phosphatase PTPL1 alters cell cycle and upregulates invasion-related genes in prostate cancer cells.Clinical & experimental metastasis · 2012Article
- Missense polymorphisms of PTPRJ and PTPN13 genes affect susceptibility to a variety of human cancers.Journal of cancer research and clinical oncology · 2010Article
- Expression of the putative tumor suppressor gene PTPN13/PTPL1 is an independent prognostic marker for overall survival in breast cancer.International journal of cancer · 2009Article
- PTPL1: a large phosphatase with a split personality.Cancer metastasis reviews · 2008Review
- Association of tyrosine phosphatase epsilon with microtubules inhibits phosphatase activity and is regulated by the epidermal growth factor receptor.Molecular and cellular biology · 2007Article
- PTPL1/FAP-1 negatively regulates TRIP6 function in lysophosphatidic acid-induced cell migration.The Journal of biological chemistry · 2007Article
- Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and exit from cytokinesis.The EMBO journal · 2007Article
- Subcellular localization and differentiation-induced redistribution of the protein tyrosine phosphatase PTP-BL in Neuroblastoma cells.Cellular and molecular neurobiology · 2005Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PTP-BL is a highly modular protein tyrosine phosphatase of unknown function. It consists of an N-terminal FERM domain, five PDZ domains, and a C-terminally located tyrosine phosphatase domain. Here we show that PTP-BL is involved in the regulation of cytokinesis. We demonstrate localization of endogenous PTP-BL at the centrosomes during inter- and metaphase and at the spindle midzone during anaphase. Finally PTP-BL is concentrated at the midbody in cytokinesis. We show that PTP-BL is targeted to the midbody and centrosome by a specific splicing variant of the N-terminus characterized by an insertion of 182 amino acids. Moreover, we demonstrate that the FERM domain of PTP-BL is associated with the contractile ring and can be cosedimented with filamentous actin, whereas the N-terminus can be cosedimented with microtubules. We demonstrate that elevating the expression level of wild-type PTP-BL or expression of PTP-BL with an inactive tyrosine phosphatase domain leads to defects in cytokinesis and to the generation of multinucleate cells. We suggest that PTP-BL plays a role in the regulation of cytokinesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.