ArticleMolecular biology of the cell2003
A balance of capping protein and profilin functions is required to regulate actin polymerization in Drosophila bristle.
Article in Molecular biology of the cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
- The actin cytoskeleton plays multiple roles in structural colour formation in butterfly wing scales.Nature communications · 2024Article
- RNP components condense into repressive RNP granules in the aging brain.Nature communications · 2022Article
- TheFrontiers in cellular and infection microbiology · 2022Article
- Profilin and Mical combine to impair F-actin assembly and promote disassembly and remodeling.Nature communications · 2021Article
- Recapitulating Actin Module Organization in theInternational journal of molecular sciences · 2021Article
- Sizes of actin networks sharing a common environment are determined by the relative rates of assembly.PLoS biology · 2019Article
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- Global treadmilling coordinates actin turnover and controls the size of actin networks.Nature reviews. Molecular cell biology · 2017Review
- IKKε inhibits PKC to promote Fascin-dependent actin bundling.Development (Cambridge, England) · 2016Article
- Profilin modulates sarcomeric organization and mediates cardiomyocyte hypertrophy.Cardiovascular research · 2016Article
- The availability of filament ends modulates actin stochastic dynamics in live plant cells.Molecular biology of the cell · 2014Article
- Regulators of the actin cytoskeleton mediate lethality in a Caenorhabditis elegans dhc-1 mutant.Molecular biology of the cell · 2010Article
- Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis.Developmental biology · 2009Article
- Expression of expanded polyglutamine targets profilin for degradation and alters actin dynamics.Neurobiology of disease · 2008Article
- The Drosophila CD2AP/CIN85 orthologue Cindr regulates junctions and cytoskeleton dynamics during tissue patterning.The Journal of cell biology · 2008Article
- New insights into mechanism and regulation of actin capping protein.International review of cell and molecular biology · 2008Review
- The flare gene, which encodes the AIP1 protein of Drosophila, functions to regulate F-actin disassembly in pupal epidermal cells.Genetics · 2007Article
- Drosophila as a genetic and cellular model for studies on axonal growth.Neural development · 2007Review
- Capping protein and the Arp2/3 complex regulate nonbundle actin filament assembly to indirectly control actin bundle positioning during Drosophila melanogaster bristle development.Molecular biology of the cell · 2006Article
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2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Profilin is a well-characterized protein known to be important for regulating actin filament assembly. Relatively few studies have addressed how profilin interacts with other actin-binding proteins in vivo to regulate assembly of complex actin structures. To investigate the function of profilin in the context of a differentiating cell, we have studied an instructive genetic interaction between mutations in profilin (chickadee) and capping protein (cpb). Capping protein is the principal protein in cells that caps actin filament barbed ends. When its function is reduced in the Drosophila bristle, F-actin levels increase and the actin cytoskeleton becomes disorganized, causing abnormal bristle morphology. chickadee mutations suppress the abnormal bristle phenotype and associated abnormalities of the actin cytoskeleton seen in cpb mutants. Furthermore, overexpression of profilin in the bristle mimics many features of the cpb loss-of-function phenotype. The interaction between cpb and chickadee suggests that profilin promotes actin assembly in the bristle and that a balance between capping protein and profilin activities is important for the proper regulation of F-actin levels. Furthermore, this balance of activities affects the association of actin structures with the membrane, suggesting a link between actin filament dynamics and localization of actin structures within the cell.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.