ArticleMolecular and cellular biology2003
Identification of homeodomain proteins, PBX1 and PREP1, involved in the transcription of murine leukemia virus.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- The Ring Finger Protein RNF6 Induces Leukemia Cell Proliferation as a Direct Target of Pre-B-cell Leukemia Homeobox 1.The Journal of biological chemistry · 2016Article
- Novel neuroprotective GSK-3β inhibitor restricts Tat-mediated HIV-1 replication.Journal of virology · 2014Article
- ZASC1 knockout mice exhibit an early bone marrow-specific defect in murine leukemia virus replication.Virology journal · 2013Article
- Effect of mimetic CDK9 inhibitors on HIV-1-activated transcription.Journal of molecular biology · 2013Article
- Article
- Unbiased proteomic analysis of proteins interacting with the HIV-1 5'LTR sequence: role of the transcription factor Meis.Nucleic acids research · 2012Article
- microRNA machinery is an integral component of drug-induced transcription inhibition in HIV-1 infection.Journal of RNAi and gene silencing : an international journal of RNA and gene targeting research · 2010Article
- Ancient, independent evolution and distinct molecular features of the novel human T-lymphotropic virus type 4.Retrovirology · 2009Article
- Prep1/Pbx2 complexes regulate CCL2 expression through the -2578 guanine polymorphism.Genes and immunity · 2008Article
- XBP-1, a novel human T-lymphotropic virus type 1 (HTLV-1) tax binding protein, activates HTLV-1 basal and tax-activated transcription.Journal of virology · 2008Article
- Delayed biosynthesis of varicella-zoster virus glycoprotein C: upregulation by hexamethylene bisacetamide and retinoic acid treatment of infected cells.Journal of virology · 2006Article
- Roscovitine inhibits activation of promoters in herpes simplex virus type 1 genomes independently of promoter-specific factors.Journal of virology · 2004Article
- Genome-scale functional profiling of the mammalian AP-1 signaling pathway.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyclin-dependent kinase inhibitors (CDKIs) have been shown to block human immunodeficiency virus and herpes simplex virus. It is hypothesized that CDKIs block viral replication by inhibiting transcription of specific cellular genes. Here we find that three CDKIs, flavopiridol, purvalanol A, and methoxy-roscovitine, block Moloney murine leukemia virus (MLV) transcription events. Using gene expression microarray technology to examine the inhibitory effects of CDKIs, we observed a cellular gene, the pre-B-cell leukemia transcription factor 1 (Pbx1) gene, down-regulated by CDKI treatment. The PBX consensus element (PCE), TGATTGAC, is conserved in the long terminal repeats of several murine retroviruses, including Moloney MLV. Mutations in the PCE completely inhibited viral transcription whereas overexpression of PBX1 and a PBX1-associated protein, PREP1, enhanced viral transcription. The interaction between the PCE and PBX1-PREP1 proteins was confirmed by gel shift experiments. Blocking PBX1 protein synthesis resulted in a significant decrease in viral transcription. Collectively, our results represent the first work demonstrating that the homeodomain proteins PBX1 and PREP1 are cellular factors involved in Moloney MLV transcription regulation.
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