ArticleMolecular and cellular biology2003
Critical role for mouse Hus1 in an S-phase DNA damage cell cycle checkpoint.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 71 citations in OpenAlex.
- DNA Damage Responses, the Trump Card of Stem Cells in the Survival Game.Advances in experimental medicine and biology · 2024Review
- Regulating cell fate of human amnion epithelial cells using natural compounds: an example of enhanced neural and pigment differentiation by 3,4,5-tri-O-caffeoylquinic acid.Cell communication and signaling : CCS · 2021Article
- Article
- Functional compartmentalization of Rad9 and Hus1 reveals diverse assembly of the 9-1-1 complex components during the DNA damage response in Leishmania.Molecular microbiology · 2016Article
- Article
- Anti-tumor activity of Eurycoma longifolia root extracts against K-562 cell line: in vitro and in vivo study.PloS one · 2014Article
- Expression of cell cycle regulatory factors hus1, gadd45a, rb1, cdkn2a and mre11a correlates with expression of clock gene per2 in human colorectal carcinoma tissue.Molecular biology reports · 2013Article
- Benzo(a)pyrene modulates fluoranthene-induced cellular responses in HT-29 colon cells in a dual exposure system.Environmental toxicology and pharmacology · 2013Article
- Chemoprevention of benzo(a)pyrene-induced colon polyps in ApcMin mice by resveratrol.The Journal of nutritional biochemistry · 2013Article
- Article
- Cytolethal distending toxin: a conserved bacterial genotoxin that blocks cell cycle progression, leading to apoptosis of a broad range of mammalian cell lineages.Microbiology (Reading, England) · 2011Review
- Targeted deletion of mouse Rad1 leads to deficient cellular DNA damage responses.Protein & cell · 2011Article
- Human RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaks.PloS one · 2011Article
- Differential Dynamics of ATR-Mediated Checkpoint Regulators.Journal of nucleic acids · 2010Article
- The human intra-S checkpoint response to UVC-induced DNA damage.Carcinogenesis · 2010Review
- Loss of Hus1 sensitizes cells to etoposide-induced apoptosis by regulating BH3-only proteins.Oncogene · 2008Article
- Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3beta.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Drosophila brca2 is required for mitotic and meiotic DNA repair and efficient activation of the meiotic recombination checkpoint.PLoS genetics · 2008Article
- The Caenorhabditis elegans Rad17 homolog HPR-17 is required for telomere replication.Genetics · 2007Article
- The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement.Molecular and cellular biology · 2007Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Mouse Hus1 encodes an evolutionarily conserved DNA damage response protein. In this study we examined how targeted deletion of Hus1 affects cell cycle checkpoint responses to genotoxic stress. Unlike hus1(-) fission yeast (Schizosaccharomyces pombe) cells, which are defective for the G(2)/M DNA damage checkpoint, Hus1-null mouse cells did not inappropriately enter mitosis following genotoxin treatment. However, Hus1-deficient cells displayed a striking S-phase DNA damage checkpoint defect. Whereas wild-type cells transiently repressed DNA replication in response to benzo(a)pyrene dihydrodiol epoxide (BPDE), a genotoxin that causes bulky DNA adducts, Hus1-null cells maintained relatively high levels of DNA synthesis following treatment with this agent. However, when treated with DNA strand break-inducing agents such as ionizing radiation (IR), Hus1-deficient cells showed intact S-phase checkpoint responses. Conversely, checkpoint-mediated inhibition of DNA synthesis in response to BPDE did not require NBS1, a component of the IR-responsive S-phase checkpoint pathway. Taken together, these results demonstrate that Hus1 is required specifically for one of two separable mammalian checkpoint pathways that respond to distinct forms of genome damage during S phase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.