ArticleGenome research2003
Multiple cross and inbred strain haplotype mapping of complex-trait candidate genes.
Article in Genome research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 72 citations in OpenAlex.
- Comparative genomic analyses of multiple backcross mouse populations suggest SGCG as a novel potential obesity-modifier gene.Human molecular genetics · 2022Article
- Genetic insights into the morass of metastatic heterogeneity.Nature reviews. Cancer · 2018Review
- The role of individual inheritance in tumor progression and metastasis.Journal of molecular medicine (Berlin, Germany) · 2015Review
- An integrative genomic analysis of the superior fecundity phenotype in QSi5 mice.Molecular biotechnology · 2013Article
- Natural genetic variation of integrin alpha L (Itgal) modulates ischemic brain injury in stroke.PLoS genetics · 2013Article
- Varying coefficient models for mapping quantitative trait loci using recombinant inbred intercrosses.Genetics · 2012Article
- Forward genetic approaches to understanding complex behaviors.Current topics in behavioral neurosciences · 2012Review
- Genetic dissection of testis weight in mice: quantitative trait locus analysis using F(2) intercrosses between strains with extreme testis weight, and association study using Y-consomic strains.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Vesico-ureteric reflux: using mouse models to understand a common congenital urinary tract defect.Pediatric nephrology (Berlin, Germany) · 2011Article
- Cancer evolution and individual susceptibility.Integrative biology : quantitative biosciences from nano to macro · 2011Review
- Mapping quantitative traits and strategies to find quantitative trait genes.Methods (San Diego, Calif.) · 2011Review
- A novel strategy for genetic dissection of complex traits: the population of specific chromosome substitution strains from laboratory and wild mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Review
- Assessing the prospects of genome-wide association studies performed in inbred mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Article
- Genetically engineered mouse models in cancer research.Advances in cancer research · 2010Review
- Lessons in signaling and tumorigenesis from polyomavirus middle T antigen.Microbiology and molecular biology reviews : MMBR · 2009Review
- Fine mapping of an epilepsy modifier gene on mouse Chromosome 19.Mammalian genome : official journal of the International Mammalian Genome Society · 2009Article
- Gene expression profiles and breast cancer metastasis: a genetic perspective.Clinical & experimental metastasis · 2009Review
- Article
- Quantitative trait loci for BMD in an SM/J by NZB/BlNJ intercross population and identification of Trps1 as a probable candidate gene.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2008Article
- Mouse modifier genes in mammary tumorigenesis and metastasis.Journal of mammary gland biology and neoplasia · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Identifying complex-trait candidate genes after initial low-resolution mapping has proven to be a difficult and labor-intensive undertaking, usually requiring years to develop and analyze congenic strains. As a result, to date, few complex-trait genes have been discovered. Recently it was suggested that SNP haplotype analysis in inbred strains might be useful for mapping of complex traits. In this study, we have combined medium-resolution haplotype mapping with multiple experimental cross-mapping experiments to reduce the number of potential candidate genes in a complex-trait candidate interval. Coincident mapping of a modifier gene in multiple experimental crosses using different inbred strains is consistent with the common inheritance of a modifier allele. A haplotype map was developed in four inbred strains of mice used in our complex-trait mapping crosses across the proximal 10 cM of proximal Chromosome 19 to identify haplotype blocks that segregate appropriately. Only ~23 out of >400 genes met this criteria. This strategy coupled with tissue and expression arrays, as well as our recently described common pathway analysis to reduce the number of high-priority candidates, may provide a rapid, efficient method to identify and prioritize complex-trait candidate genes without requiring construction of congenic mouse strains.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.