ArticleGenome research2003
Reevaluating human gene annotation: a second-generation analysis of chromosome 22.
Article in Genome research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Developmental transcriptome analysis of human erythropoiesis.Human molecular genetics · 2014Article
- Article
- The solute carrier families have a remarkably long evolutionary history with the majority of the human families present before divergence of Bilaterian species.Molecular biology and evolution · 2011Article
- Finishing the finished human chromosome 22 sequence.Genome biology · 2008Article
- Pseudogene.org: a comprehensive database and comparison platform for pseudogene annotation.Nucleic acids research · 2007Article
- Gene prediction in eukaryotes with a generalized hidden Markov model that uses hints from external sources.BMC bioinformatics · 2006Article
- EGASP: the human ENCODE Genome Annotation Assessment Project.Genome biology · 2006Review
- Using several pair-wise informant sequences for de novo prediction of alternatively spliced transcripts.Genome biology · 2006Article
- Abundant novel transcriptional units and unconventional gene pairs on human chromosome 22.Genome research · 2006Article
- What can we learn from noncoding regions of similarity between genomes?BMC bioinformatics · 2004Article
- CREB binds to multiple loci on human chromosome 22.Molecular and cellular biology · 2004Article
- The otter annotation system.Genome research · 2004Article
- Article
- Numerous novel annotations of the human genome sequence supported by a 5'-end-enriched cDNA collection.Genome research · 2004Article
- Novel RNAs identified from an in-depth analysis of the transcriptome of human chromosomes 21 and 22.Genome research · 2004Article
- A comprehensive transcript index of the human genome generated using microarrays and computational approaches.Genome biology · 2004Article
- After 'completion': the changing face of human chromosomes 21 and 22.Genome biology · 2004Review
- A genome annotation-driven approach to cloning the human ORFeome.Genome biology · 2004Article
- The truth about mouse, human, worms and yeast.Human genomics · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
We report a second-generation gene annotation of human chromosome 22. Using expressed sequence databases, comparative sequence analysis, and experimental verification, we have extended genes, fused previously fragmented structures, and identified new genes. The total length in exons of annotation was increased by 74% over our previously published annotation and includes 546 protein-coding genes and 234 pseudogenes. Thirty-two potential protein-coding annotations are partial copies of other genes, and may represent duplications on an evolutionary path to change or loss of function. We also identified 31 non-protein-coding transcripts, including 16 possible antisense RNAs. By extrapolation, we estimate the human genome contains 29,000-36,000 protein-coding genes, 21,300 pseudogenes, and 1500 antisense RNAs. We suggest that our revised annotation criteria provide a paradigm for future annotation of the human genome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.