ArticleGenome research2003
Covariation in frequencies of substitution, deletion, transposition, and recombination during eutherian evolution.
Article in Genome research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
158 citing papers in PubMed, 290 citations in OpenAlex.
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- The large single-copy (LSC) region functions as a highly effective and efficient molecular marker for accurate authentication of medicinalActa pharmaceutica Sinica. B · 2020Article
- Ancestral Reconstruction of Karyotypes Reveals an Exceptional Rate of Nonrandom Chromosomal Evolution in Sunflower.Genetics · 2020Article
- Mutational Dynamics of Aroid Chloroplast Genomes II.Frontiers in genetics · 2020Article
- Similarities and differences in patterns of germline mutation between mice and humans.Nature communications · 2019Article
- Significant Strain Variation in the Mutation Spectra of Inbred Laboratory Mice.Molecular biology and evolution · 2019Article
- The poplar pangenome provides insights into the evolutionary history of the genus.Communications biology · 2019Article
- Germline DNA replication timing shapes mammalian genome composition.Nucleic acids research · 2018Article
- Divergent genome evolution caused by regional variation in DNA gain and loss between human and mouse.PLoS computational biology · 2018Article
- Mechanisms and consequences of diversity-generating immune strategies.Nature reviews. Immunology · 2017Review
- Ribosomal RNA Genes Contribute to the Formation of Pseudogenes and Junk DNA in the Human Genome.Genome biology and evolution · 2017Article
- Finding the Genomic Basis of Local Adaptation: Pitfalls, Practical Solutions, and Future Directions.The American naturalist · 2016Review
- Determining the Effect of Natural Selection on Linked Neutral Divergence across Species.PLoS genetics · 2016Article
98 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 1 institution in 2 countries.
Funding
Abstract
Six measures of evolutionary change in the human genome were studied, three derived from the aligned human and mouse genomes in conjunction with the Mouse Genome Sequencing Consortium, consisting of (1) nucleotide substitution per fourfold degenerate site in coding regions, (2) nucleotide substitution per site in relics of transposable elements active only before the human-mouse speciation, and (3) the nonaligning fraction of human DNA that is nonrepetitive or in ancestral repeats; and three derived from human genome data alone, consisting of (4) SNP density, (5) frequency of insertion of transposable elements, and (6) rate of recombination. Features 1 and 2 are measures of nucleotide substitutions at two classes of "neutral" sites, whereas 4 is a measure of recent mutations. Feature 3 is a measure dominated by deletions in mouse, whereas 5 represents insertions in human. It was found that all six vary significantly in megabase-sized regions genome-wide, and many vary together. This indicates that some regions of a genome change slowly by all processes that alter DNA, and others change faster. Regional variation in all processes is correlated with, but not completely accounted for, by GC content in human and the difference between GC content in human and mouse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.