ArticleThe Biochemical journal2003
Nitrogen-source regulation of yeast gamma-glutamyl transpeptidase synthesis involves the regulatory network including the GATA zinc-finger factors Gln3, Nil1/Gat1 and Gzf3.
Article in The Biochemical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Proteomics ofJournal of fungi (Basel, Switzerland) · 2023Article
- Chromatin Regulators Ahc1p and Eaf3p Positively Influence Nitrogen Metabolism inFrontiers in microbiology · 2022Article
- Yeast Assimilable Nitrogen Concentrations Influence Yeast Gene Expression and Hydrogen Sulfide Production During Cider Fermentation.Frontiers in microbiology · 2020Article
- Differential Gene Expression and Allele Frequency Changes Favour Adaptation of a Heterogeneous Yeast Population to Nitrogen-Limited Fermentations.Frontiers in microbiology · 2020Article
- Review
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- An Autophagy-Independent Role forGenetics · 2018Article
- Optimization of Reduced Glutathione Production by aFrontiers in microbiology · 2017Article
- Glutathione degradation by the alternative pathway (DUG pathway) in Saccharomyces cerevisiae is initiated by (Dug2p-Dug3p)2 complex, a novel glutamine amidotransferase (GATase) enzyme acting on glutathione.The Journal of biological chemistry · 2012Article
- The yeast GATA factor Gat1 occupies a central position in nitrogen catabolite repression-sensitive gene activation.Molecular and cellular biology · 2009Article
- Glutathione participates in the regulation of mitophagy in yeast.The Journal of biological chemistry · 2009Article
- Histoplasma capsulatum secreted gamma-glutamyltransferase reduces iron by generating an efficient ferric reductant.Molecular microbiology · 2008Article
- Molecular cloning, characterization and regulation of a peroxiredoxin gene from Schizosaccharomyces pombe.Molecular biology reports · 2008Article
- Oxidant resistance in a yeast mutant deficient in the Sit4 phosphatase.Current genetics · 2008Article
- Nitrogen depletion causes up-regulation of glutathione content and gamma-glutamyltranspeptidase in Schizosaccharomyces pombe.Journal of microbiology (Seoul, Korea) · 2008Article
- Cloning, characterization and regulation of a protein disulfide isomerase from the fission yeast Schizosaccharomyces pombe.Molecular biology reports · 2006Article
- In vivo specificity of Ure2 protection from heavy metal ion and oxidative cellular damage in Saccharomyces cerevisiae.Yeast (Chichester, England) · 2005Article
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Abstract
In Saccharomyces cerevisiae, the CIS2 gene encodes gamma-glutamyl transpeptidase (gamma-GT; EC 2.3.2.2), the main GSH-degrading enzyme. The promoter region of CIS2 contains one stress-response element (CCCCT) and eight GAT(T/A)A core sequences, probably involved in nitrogen-regulated transcription. We show in the present study that expression of CIS2 is indeed regulated according to the nature of the nitrogen source. Expression is highest in cells growing on a poor nitrogen source such as urea. Under these conditions, the GATA zinc-finger transcription factors Nil1 and Gln3 are both required for CIS2 expression, Nil1 appearing as the more important factor. We further show that Gzf3, another GATA zinc-finger protein, acts as a negative regulator in nitrogen-source control of CIS2 expression. During growth on a preferred nitrogen source like NH(4)(+), CIS2 expression is repressed through a mechanism involving (at least) the Gln3-binding protein Ure2/GdhCR. Induction of CIS2 expression during nitrogen starvation is dependent on Gln3 and Nil1. Furthermore, rapamycin causes similar CIS2 activation, indicating that the target of rapamycin signalling pathway controls CIS2 expression via Gln3 and Nil1 in nitrogen-starved cells. Finally, our results show that CIS2 expression is induced mainly by nitrogen starvation but apparently not by other types of stress.
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