ArticleNucleic acids research2003
Selections for constituting new RNA-protein interactions in catalytic RNP.
Article in Nucleic acids research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Arginine cofactors on the polymerase ribozyme.PloS one · 2011Article
- Selection of a novel class of RNA-RNA interaction motifs based on the ligase ribozyme with defined modular architecture.Nucleic acids research · 2008Article
- Generation of a catalytic module on a self-folding RNA.RNA (New York, N.Y.) · 2004Article
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In vitro and in vivo selection techniques are developed to constitute new RNA-peptide interactions. The selection strategy is designed by employing a catalytic RNP consisting of a derivative of the Tetrahymena ribozyme and an artificial RNA-binding protein. An arginine-rich RNA-binding motif and its target RNA motif in the RNP are substituted with randomized sequences and used for the selection experiments. Previously unknown binding motifs are obtained and the newly established interactions have been indispensable for assembling a catalytically active RNP. The method employed in this study is useful for making customized self-splicing intron RNAs whose activity is regulated by protein cofactors.
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