ArticleThe Journal of physiology2003
Activation of mGlu receptors induces LTD without affecting postsynaptic sensitivity of CA1 neurons in rat hippocampal slices.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Selective Recruitment of Presynaptic and Postsynaptic Forms of mGluR-LTD.Frontiers in synaptic neuroscience · 2022Article
- Article
- Diacylglycerol Kinases in the Coordination of Synaptic Plasticity.Frontiers in cell and developmental biology · 2016Review
- Article
- Role of presynaptic metabotropic glutamate receptors in the induction of long-term synaptic plasticity of vesicular release.Neuropharmacology · 2013Review
- A novel non-CB1/TRPV1 endocannabinoid-mediated mechanism depresses excitatory synapses on hippocampal CA1 interneurons.Hippocampus · 2012Article
- Steroid modulation of hippocampal plasticity: switching between cognitive and emotional memories.Frontiers in cellular neuroscience · 2012Article
- Differential trafficking of AMPA receptors following activation of NMDA receptors and mGluRs.Molecular brain · 2011Article
- DGKι regulates presynaptic release during mGluR-dependent LTD.The EMBO journal · 2011Article
- Endocannabinoids differentially modulate synaptic plasticity in rat hippocampal CA1 pyramidal neurons.PloS one · 2010Article
- Presynaptic m1 muscarinic receptors are necessary for mGluR long-term depression in the hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Metabotropic glutamate receptor-mediated long-term depression: molecular mechanisms.Pharmacological reviews · 2009Review
- Plasticity of intrinsic excitability during long-term depression is mediated through mGluR-dependent changes in I(h) in hippocampal CA1 pyramidal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Exocytosis of vesicular zinc reveals persistent depression of neurotransmitter release during metabotropic glutamate receptor long-term depression at the hippocampal CA3-CA1 synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Cannabinoid receptor type 1 located on presynaptic terminals of principal neurons in the forebrain controls glutamatergic synaptic transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Tyrosine phosphatases regulate AMPA receptor trafficking during metabotropic glutamate receptor-mediated long-term depression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Leptin induces a novel form of NMDA receptor-dependent long-term depression.Journal of neurochemistry · 2005Article
- Developmental switch in synaptic mechanisms of hippocampal metabotropic glutamate receptor-dependent long-term depression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Bi-directional modulation of AMPA receptor unitary conductance by synaptic activity.BMC neuroscience · 2004Article
- Extracellular signal-regulated protein kinase activation is required for metabotropic glutamate receptor-dependent long-term depression in hippocampal area CA1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two forms of long-term depression (LTD) of excitatory synaptic transmission have been identified in the mammalian CNS, which are induced by the synaptic activation of N-methyl-D-aspartate (NMDA) and metabotropic glutamate (mGlu) receptors, respectively. The mGlu receptor-dependent form of LTD can be activated by application of 3,5-dihydroxyphenylglycine (DHPG), a group I selective mGlu receptor agonist. DHPG-induced LTD is increasingly being used to investigate the mechanisms of mGlu receptor-dependent LTD. However, recent experiments have argued for both a pre- and postsynaptic locus of expression of DHPG-induced LTD. In the present study we report that DHPG-induced LTD is not associated with changes in the sensitivity of CA1 neurons to bath applied AMPA. Furthermore, in contrast to homosynaptic LTD, DHPG-induced LTD is also not associated with changes in sensitivity to focally uncaged L-glutamate. These data do not support the notion that DHPG-induced LTD requires a modification of AMPA receptors, such as their internalisation, but are compatible with a presynaptic mechanism of expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.