ArticleThe Journal of physiology2003
Muscarinic regulation of pacemaker frequency in murine gastric interstitial cells of Cajal.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 77 citations in OpenAlex.
- Comparison of selective M3 and nonselective muscarinic receptor antagonists on gastrointestinal transit and bowel habits in humans.American journal of physiology. Gastrointestinal and liver physiology · 2010Trial
- Interstitial cells of the sip syncytium regulate basal membrane potential in murine gastric corpus.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- 5-Hydroxytryptamine Enhances the Pacemaker Activity of Interstitial Cells of Cajal in Mouse Colon.International journal of molecular sciences · 2024Article
- Neural regulation of slow waves and phasic contractions in the distal stomach: a mathematical model.Journal of neural engineering · 2024Article
- Functional and Transcriptomic Characterization of Postnatal Maturation of ENS and SIP Syncytium in Mice Colon.Biomolecules · 2023Article
- Synergistic augmentation of rhythmic myogenic contractions of human stomach by arginine vasopressin and adrenaline: Implications for the induction of nausea.British journal of pharmacology · 2022Article
- Evidence for tetrodotoxin-resistant spontaneous myogenic contractions of mouse isolated stomach that are dependent on acetylcholine.British journal of pharmacology · 2022Article
- Overexpression of Stromal Interaction Molecule 1/Store-operated Calcium Entry-associated Regulatory Factor in Interstitial Cells of Cajal in Mouse Jejunum Impairs Pacemaker Activity.Journal of neurogastroenterology and motility · 2018Article
- Analysis of spatiotemporal pattern and quantification of gastrointestinal slow waves caused by anticholinergic drugs.Organogenesis · 2017Article
- Regulation of gastric electrical and mechanical activity by cholinesterases in mice.Journal of neurogastroenterology and motility · 2015Article
- Quantification of in vivo colonic motor patterns in healthy humans before and after a meal revealed by high-resolution fiber-optic manometry.Neurogastroenterology and motility · 2014Article
- Enteric sensory neurons communicate with interstitial cells of Cajal to affect pacemaker activity in the small intestine.Pflugers Archiv : European journal of physiology · 2014Article
- A biophysically based finite-state machine model for analyzing gastric experimental entrainment and pacing recordings.Annals of biomedical engineering · 2014Article
- Article
- Interstitial cells of Cajal: update on basic and clinical science.Current gastroenterology reports · 2014Review
- A case of treatment refractory hyperemesis gravidarum in a patient with comorbid anxiety, treated successfully with adjunctive gabapentin: a review and the potential role of neurogastroentereology in understanding its pathogenesis and treatment.Innovations in clinical neuroscience · 2012Article
- The important roles of interstitial cells of cajal and cholinergic receptors on diabetes related dysfunction of colon.Journal of neurogastroenterology and motility · 2011Article
- Muscarinic activation of Ca2+-activated Cl- current in interstitial cells of Cajal.The Journal of physiology · 2011Article
- The PI-PLC inhibitor U-73122 is a potent inhibitor of the SERCA pump in smooth muscle.British journal of pharmacology · 2010Article
- Physiology, injury, and recovery of interstitial cells of Cajal: basic and clinical science.Gastroenterology · 2009Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Peristaltic contractions in the stomach are regulated by the spread of electrical slow waves from the corpus to the pylorus. Gastric slow waves are generated and propagated by the interstitial cells of Cajal (ICC). All regions distal to the dominant pacemaker area in the corpus are capable of generating slow waves, but orderly gastric peristalsis depends upon a frequency gradient in which the corpus pacemaker frequency exceeds the antral frequency. Cholinergic, muscarinic stimulation enhances pacemaker frequency. We investigated this phenomenon using intact murine gastric muscles and cultured ICC. Acetylcholine (ACh) increased the frequency of slow waves in antrum and corpus muscles. The increase was significantly greater in the antrum. ACh and carbachol (CCh) increased the pacemaker currents in cultured ICC. At high doses of CCh, transient pacemaker currents fused into sustained inward currents that persisted for the duration of stimulation. The effects of CCh were blocked by low doses of the M(3) receptor antagonist 1-dimethyl-4-diphenylacetoxypiperidinium. Frequency enhancement by CCh was not affected by forskolin, but the phospholipase C inhibitor U-73122 inhibited both the increase in frequency and the development of tonic inward currents. 2-Aminoethyldiphenyl borate also blocked the chronotropic responses to CCh. Inhibitors of protein kinase C did not block responses to CCh. These studies show that mice are an excellent model for studying mechanisms that regulate gastric slow-wave frequency. CCh, apparently via production of inositol 1,4,5-trisphosphate, accelerates the frequency of pacemaker activity. High concentrations of CCh may block the entrainment of pacemaker currents, resulting in a tonic inward current.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.