ArticleThe Journal of physiology2003
Multidrug resistance transporters in the olfactory receptor neurons of Xenopus laevis tadpoles.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
- Calcium imaging of adult olfactory epithelium reveals amines as important odor class in fish.Cell and tissue research · 2024Article
- Resolving different presynaptic activity patterns within single olfactory glomeruli of Xenopus laevis larvae.Scientific reports · 2021Article
- Anatomical and functional analysis of domestication effects on the olfactory system of the silkmoth Bombyx mori.Proceedings. Biological sciences · 2014Article
- Phospholipase C and diacylglycerol mediate olfactory responses to amino acids in the main olfactory epithelium of an amphibian.PloS one · 2014Article
- Bimodal processing of olfactory information in an amphibian nose: odor responses segregate into a medial and a lateral stream.Cellular and molecular life sciences : CMLS · 2013Article
- Mechanisms of constitutive and ATP-evoked ATP release in neonatal mouse olfactory epithelium.BMC neuroscience · 2012Article
- Amino acid- vs. peptide-odorants: responses of individual olfactory receptor neurons in an aquatic species.PloS one · 2012Article
- Functional evidence of multidrug resistance transporters (MDR) in rodent olfactory epithelium.PloS one · 2012Article
- Article
- Slice cultures as a model to study neurovascular coupling and blood brain barrier in vitro.Cardiovascular psychiatry and neurology · 2011Article
- The endocannabinoid 2-arachidonoyl-glycerol controls odor sensitivity in larvae of Xenopus laevis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- A new challenge-development of test systems for the infochemical effect.Environmental science and pollution research international · 2009Review
- The infochemical effect-a new chapter in ecotoxicology.Environmental science and pollution research international · 2008Article
- The effect of external sodium concentration on sodium-calcium exchange in frog olfactory receptor cells.The Journal of physiology · 2007Article
- Response profiles to amino acid odorants of olfactory glomeruli in larval Xenopus laevis.The Journal of physiology · 2007Article
- Cannabinoid action in the olfactory epithelium.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Transport of estrone sulfate by the novel organic anion transporter Oat6 (Slc22a20).American journal of physiology. Renal physiology · 2006Article
- Functional evidence for P-glycoprotein at the nose-brain barrier.Pharmaceutical research · 2005Article
- Classes and narrowing selectivity of olfactory receptor neurons of Xenopus laevis tadpoles.The Journal of general physiology · 2004Article
- cAMP-independent olfactory transduction of amino acids in Xenopus laevis tadpoles.The Journal of physiology · 2003Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Olfactory receptor neurons (ORNs) are the only class of neurons that is directly exposed to the environment. Therefore, they need to deal with xenobiotic and potentially cytotoxic substances. Here we show for the first time that ORNs possess transporter systems that expel xenobiotics across the plasma membrane. Using calcein and calcium-indicator dyes as xenobiotics, we demonstrate that ORNs appear to express the multidrug resistance P-glycoprotein (MDR1) and multidrug resistance-associated proteins (MRP). This endows ORNs with the ability to transport a large number of substrates including calcium-indicator dyes and calcein across their plasma membranes. Conversely, blocking P-glycoprotein and MRP increases the net uptake of these dyes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.