ArticlePediatric pulmonology2003
Role of viruses and atypical bacteria in exacerbations of asthma in hospitalized children: a prospective study in the Nord-Pas de Calais region (France).
Article in Pediatric pulmonology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01449435 (Asthma Exacerbations in Young Children With Moderate Asthma - Prospective Evaluation of Predictors), which is not on this map. Cited by 51 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Asthma Exacerbations in Young Children With Moderate Asthma - Prospective Evaluation of Predictors
Who cites it
51 citing papers in PubMed, 3 syntheses or guidelines pooled it, 130 citations in OpenAlex.
- Prevalence of respiratory viruses in stable and acute asthma: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Interventions for autumn exacerbations of asthma in children.The Cochrane database of systematic reviews · 2018Pooled it
- Pooled it
- Can a school-based hand hygiene program reduce asthma exacerbations among elementary school children?The Journal of allergy and clinical immunology · 2012Trial
- Redesigning a large school-based clinical trial in response to changes in community practice.Clinical trials (London, England) · 2011Trial
- Virological Profile of Asthma Exacerbation in Children: A Hospital-Based Retrospective Study.Cureus · 2024Article
- A comprehensive review ofFrontiers in medicine · 2024Review
- Lockdown Fatigue in Pediatric Respiratory Patients: Lessons from the First COVID-19 Year.Children (Basel, Switzerland) · 2022Article
- Real-time effects of COVID-19 pandemic lockdown on pediatric respiratory patients.Pediatric pulmonology · 2021Article
- The Impact of the SARS-CoV-2 Pandemic on the Emergency Department and Management of the Pediatric Asthmatic Patient.Journal of asthma and allergy · 2021Article
- Pediatric asthma and COVID-19: The known, the unknown, and the controversial.Pediatric pulmonology · 2020Review
- Childhood asthma heterogeneity at the era of precision medicine: Modulating the immune response or the microbiota for the management of asthma attack.Biochemical pharmacology · 2020Review
- Managing Asthma during Coronavirus Disease-2019: An Example for Other Chronic Conditions in Children and Adolescents.The Journal of pediatrics · 2020Review
- Respiratory pathogens and clinical outcomes in children with an asthma exacerbation: A systematic review.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2019Review
- Molecular detection of respiratory pathogens and typing of human rhinovirus of adults hospitalized for exacerbation of asthma and chronic obstructive pulmonary disease.Respiratory research · 2019Article
- Association ofExperimental and therapeutic medicine · 2017Article
- Hospitalizations and outpatient visits for rhinovirus-associated acute respiratory illness in adults.The Journal of allergy and clinical immunology · 2016Article
- Understanding the Association of Human Rhinovirus with Asthma.Clinical and vaccine immunology : CVI · 2016Review
- [Value of routine identification of respiratory infectious agents in children hospitalized with an acute asthma exacerbation].Archives de pediatrie : organe officiel de la Societe francaise de pediatrie · 2014Article
- IL-17-producing peripheral blood CD177+ neutrophils increase in allergic asthmatic subjects.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied the role of viruses and atypical bacteria in children hospitalized with exacerbated asthma by a prospective study of children with acute asthma admitted to the Department of Pediatrics in Lille, and to 15 hospitals in the Nord-Pas de Calais region, from October 1, 1998-June 30, 1999. We included children aged 2-16 years with active asthma, defined as three or more recurrent episodes of reversible wheezing. The severity of asthma and of asthmatic exacerbations was recorded. Immunofluorescence assays (IFA) on nasopharyngeal secretions (NPS), serological tests, or both, were used for detection of influenza virus, respiratory syncytial virus (RSV), adenovirus, parainfluenza virus, and coronavirus. Polymerase chain reaction (PCR) assays on NPS were used for rhinovirus and enterovirus. Serological tests for Chlamydia pneumoniae and Mycoplasma pneumoniae were performed. A control group of asymptomatic asthmatic outpatients was examined for respiratory viruses (using IFA and PCR). Eighty-two symptomatic children (mean age, 7.9 years) were examined. Viruses were detected in 38% (enterovirus, 15.8%; rhinovirus, 12%; RSV, 7.3%). Serological tests for atypical bacteria were positive in 10% of patients (C. pneumoniae, 5%; M. pneumoniae, 5%). Among the 27 control subjects (mean age, 7.9 years), one PCR was positive for enterovirus. There was no correlation between severity of chronic asthma or asthmatic exacerbations and the diagnosis of infection. Atypical bacterial pathogen infections were linked with prolonged asthmatic symptoms. In conclusion, we confirmed the high incidence of viral infection in acute exacerbations of asthma, especially enteroviruses or rhinoviruses. Persistent clinical features were more frequently associated with atypical bacterial infections, suggesting that these infections should be investigated and treated in cases of persistent asthmatic symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.