ArticleAmerican journal of human genetics2003
Hierarchical modeling of linkage disequilibrium: genetic structure and spatial relations.
Article in American journal of human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Hierarchical joint analysis of marginal summary statistics-Part II: High-dimensional instrumental analysis of omics data.Genetic epidemiology · 2024Article
- A Hierarchical Approach Using Marginal Summary Statistics for Multiple Intermediates in a Mendelian Randomization or Transcriptome Analysis.American journal of epidemiology · 2021Article
- A hierarchical modeling approach for assessing the safety of exposure to complex antiretroviral drug regimens during pregnancy.Statistical methods in medical research · 2019Article
- A novel linkage-disequilibrium corrected genomic relationship matrix for SNP-heritability estimation and genomic prediction.Heredity · 2018Article
- Using local multiplicity to improve effect estimation from a hypothesis-generating pharmacogenetics study.The pharmacogenomics journal · 2016Article
- Integration of multiethnic fine-mapping and genomic annotation to prioritize candidate functional SNPs at prostate cancer susceptibility regions.Human molecular genetics · 2015Article
- Prediction of complex human diseases from pathway-focused candidate markers by joint estimation of marker effects: case of chronic fatigue syndrome.Human genomics · 2015Article
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- Replication of breast cancer susceptibility loci in whites and African Americans using a Bayesian approach.American journal of epidemiology · 2014Article
- Two-phase and family-based designs for next-generation sequencing studies.Frontiers in genetics · 2013Review
- Integrative variable selection via Bayesian model uncertainty.Statistics in medicine · 2013Article
- Biomarkers for smoking cessation.Clinical pharmacology and therapeutics · 2013Review
- Gene genealogies for genetic association mapping, with application to Crohn's disease.Frontiers in genetics · 2013Article
- Swift block-updating EM and pseudo-EM procedures for Bayesian shrinkage analysis of quantitative trait loci.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2012Article
- Hierarchical regression for multiple comparisons in a case-control study of occupational risks for lung cancer.PloS one · 2012Article
- Incorporating prior biologic information for high-dimensional rare variant association studies.Human heredity · 2012Article
- Gene set analysis of SNP data: benefits, challenges, and future directions.European journal of human genetics : EJHG · 2011Review
- Assessment of rare BRCA1 and BRCA2 variants of unknown significance using hierarchical modeling.Genetic epidemiology · 2011Article
- Hierarchical modeling for estimating relative risks of rare genetic variants: properties of the pseudo-likelihood method.Biometrics · 2011Article
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2 authors.
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Abstract
Linkage disequilibrium (LD) mapping offers much promise for the positional cloning of disease-causing genes. However, conventional estimates of LD may fluctuate substantially across contiguous genomic regions, because of population-specific phenomena such as mutation, genetic drift, population structure, and variations in allele frequencies. This fluctuation makes it difficult to interpret patterns of LD and distinguish where a causal gene is located. To address this issue, we propose hierarchical modeling of LD (HLD) for fine-scale mapping. This approach incorporates information on haplotype block structure and chromosomal spatial relations to refine the pattern of LD, increasing the ability to localize disease genes. Here, we present a framework for HLD, a simulation study assessing the performance of HLD under various scenarios, and an application of HLD to existing data. This work demonstrates that hierarchical modeling of linkage disequilibrium is a valuable and flexible approach for fine-scale mapping.
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