ArticleProceedings of the National Academy of Sciences of the United States of America2003
Competition for self ligands restrains homeostatic proliferation of naive CD4 T cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed.
- Distinct landscapes of T-cell immunity and TCR repertoire between sepsis and pre-septic high-risk states.Frontiers in immunology · 2026Article
- A fundamental relationship between TCR diversity, repertoire size and systemic clonal expansion: insights from 30,000 TCRFrontiers in immunology · 2025Article
- Homeostatic signals, including IL-7 and self-MHC recognition, induce the development of peripheral helper T cells, which are enriched in the joints of rheumatoid arthritis.Journal of translational autoimmunity · 2024Article
- The TCR assigns naive T cells to a preferred lymph node.Science advances · 2024Article
- Acute effects of FLT3L treatment on T cells in intact mice.Scientific reports · 2022Article
- Lymphopenia, Lymphopenia-Induced Proliferation, and Autoimmunity.International journal of molecular sciences · 2021Review
- Age is not just a number: Naive T cells increase their ability to persist in the circulation over time.PLoS biology · 2018Article
- Spontaneous Proliferation of CD4Frontiers in immunology · 2018Article
- Phenotypic and Functional Changes of Peripheral Ly6CFrontiers in immunology · 2018Article
- Interleukin-21 promotes thymopoiesis recovery following hematopoietic stem cell transplantation.Journal of hematology & oncology · 2017Article
- Gastrointestinal Microbiome Dysbiosis in Infant Mice Alters Peripheral CD8Frontiers in immunology · 2017Article
- Self-reactivity as the necessary cost of maintaining a diverse memory T-cell repertoire.Pathogens and disease · 2016Review
- How many TCR clonotypes does a body maintain?Journal of theoretical biology · 2016Article
- Establishment and Maintenance of the Human Naïve CD4Frontiers in pediatrics · 2016Review
- Innate memory T cells.Advances in immunology · 2015Review
- Naïve T Cell Homeostasis Regulated by Stress Responses and TCR Signaling.Frontiers in immunology · 2015Review
- Impact of sepsis on CD4 T cell immunity.Journal of leukocyte biology · 2014Review
- At low precursor frequencies, the T-cell response to chronic self-antigen results in anergy without deletion.European journal of immunology · 2012Article
- Subsets of nonclonal neighboring CD4+ T cells specifically regulate the frequency of individual antigen-reactive T cells.Immunity · 2012Article
- CD18 is required for optimal lymphopenia-induced proliferation of mouse T cells.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
T cell antigen receptor (TCR) diversity is a critical feature of adaptive immunity. However, restriction of TCR diversity is a potential risk during immune reconstitution by homeostatic proliferation. What peripheral mechanisms are in place to maintain TCR diversity during recovery from lymphopenia? Here, we examine competition between several monoclonal CD4 T cell populations in RAG(-/-) and TCR Tg RAG(-/-) environments. The results suggest that specific self ligands constitute a critical limiting resource essential for homeostatic proliferation of naive CD4 T cells. In addition, T cells ignore large numbers of competitors as long as their TCR specificity is different and other non-MHC resources are not limiting. Therefore, the numbers of self ligands expressed in the periphery set the limits on TCR diversity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.