ArticleJournal of virology2003
Depletion of Wee-1 kinase is necessary for both human immunodeficiency virus type 1 Vpr- and gamma irradiation-induced apoptosis.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Review
- Article
- Extra View: Sirt1 Acts As A Gatekeeper Of Replication Initiation To Preserve Genomic Stability.Nucleus (Austin, Tex.) · 2018Review
- Therapeutic doses of irradiation activate viral transcription and induce apoptosis in HIV-1 infected cells.Virology · 2015Article
- Review
- Molecular insight into how HIV-1 Vpr protein impairs cell growth through two genetically distinct pathways.The Journal of biological chemistry · 2011Article
- Roles of Vpr and Vpx in modulating the virus-host cell relationship.Molecular aspects of medicine · 2010Review
- Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase.The Journal of cell biology · 2010Article
- HIV-1 Vpr: mechanisms of G2 arrest and apoptosis.Experimental and molecular pathology · 2008Review
- Human immunodeficiency virus type 1 Vpr binds to the N lobe of the Wee1 kinase domain and enhances kinase activity for CDC2.Journal of virology · 2008Article
- Localization of HIV-1 Vpr to the nuclear envelope: impact on Vpr functions and virus replication in macrophages.Retrovirology · 2007Article
- The Vif accessory protein alters the cell cycle of human immunodeficiency virus type 1 infected cells.Virology · 2007Article
- HIV-1 Vpr-induced apoptosis is cell cycle dependent and requires Bax but not ANT.PLoS pathogens · 2006Article
- Induction of G2 arrest and binding to cyclophilin A are independent phenotypes of human immunodeficiency virus type 1 Vpr.Journal of virology · 2006Article
- Human papillomavirus type 16 E6 and E7 oncoproteins upregulate c-IAP2 gene expression and confer resistance to apoptosis.Oncogene · 2005Article
- The Vpr protein from HIV-1: distinct roles along the viral life cycle.Retrovirology · 2005Review
- Heat shock protein 70 protects cells from cell cycle arrest and apoptosis induced by human immunodeficiency virus type 1 viral protein R.Journal of virology · 2004Article
- Increased levels of Wee-1 kinase in G(2) are necessary for Vpr- and gamma irradiation-induced G(2) arrest.Journal of virology · 2004Article
- Dysregulation of the polo-like kinase pathway in CD4+ T cells is characteristic of pathogenic simian immunodeficiency virus infection.Journal of virology · 2004Article
- Recent Insights into HIV Accessory Proteins.Current infectious disease reports · 2003Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Human immunodeficiency virus (HIV) protein R (Vpr) induces G2 arrest, and prolonged G2 arrest leads to apoptosis. We find that in HeLa cells the cell cycle regulatory kinase, Wee-1, is depleted following prolonged G2 arrest induced by Vpr. Of note, small interfering RNAs directed to Wee-1 triggered apoptosis, suggesting a direct role for Wee-1 in apoptosis. In support of this hypothesis, overexpression of Wee-1 suppressed Vpr-mediated apoptosis. Importantly, similar results were observed with cells induced to undergo apoptosis gamma irradiation. Thus, Wee-1 may serve as a key regulator of both HIV type 1 Vpr- and gamma irradiation-mediated apoptosis and possibly serve as a general regulator linking the cell cycle to some pathways of apoptosis.
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Registered trials
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