ArticleJournal of virology2003
New hepatitis B virus of cranes that has an unexpected broad host range.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 60 citations in OpenAlex.
- Genetic diversity and phylogeographic dynamics of avihepadnavirus: a comprehensive full-length genomic view.Frontiers in veterinary science · 2024Article
- Genetic characterization of duck hepatitis B viruses from Anhui Province, China.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- New Avian Hepadnavirus in Palaeognathous Bird, Germany.Emerging infectious diseases · 2017Article
- Distinct Viral Lineages from Fish and Amphibians Reveal the Complex Evolutionary History of Hepadnaviruses.Journal of virology · 2016Article
- Characterization of a Novel Hepadnavirus in the White Sucker (Catostomus commersonii) from the Great Lakes Region of the United States.Journal of virology · 2015Article
- Animal models and the molecular biology of hepadnavirus infection.Cold Spring Harbor perspectives in medicine · 2015Review
- Molecular docking studies of phytochemicals from Phyllanthus niruri against Hepatitis B DNA Polymerase.Bioinformation · 2015Article
- Is hepatitis B-virucidal validation of biocides possible with the use of surrogates?World journal of gastroenterology · 2014Review
- Detection of Hepatitis B virus in serum and liver of chickens.Virology journal · 2012Article
- A high level of mutation tolerance in the multifunctional sequence encoding the RNA encapsidation signal of an avian hepatitis B virus and slow evolution rate revealed by in vivo infection.Journal of virology · 2011Article
- Genomic fossils calibrate the long-term evolution of hepadnaviruses.PLoS biology · 2010Article
- Prevalence of a virus similar to human hepatitis B virus in swine.Virology journal · 2010Article
- Pre-P is a secreted glycoprotein encoded as an N-terminal extension of the duck hepatitis B virus polymerase gene.Journal of virology · 2009Article
- Heterologous replacement of the supposed host determining region of avihepadnaviruses: high in vivo infectivity despite low infectivity for hepatocytes.PLoS pathogens · 2008Article
- Duck hepatitis B virus requires cholesterol for endosomal escape during virus entry.Journal of virology · 2008Article
- HBVRegDB: annotation, comparison, detection and visualization of regulatory elements in hepatitis B virus sequences.Virology journal · 2007Article
- Monoclonal antibodies providing topological information on the duck hepatitis B virus core protein and avihepadnaviral nucleocapsid structure.Journal of virology · 2007Article
- Avian hepatitis B viruses: molecular and cellular biology, phylogenesis, and host tropism.World journal of gastroenterology · 2007Review
- Viral and cellular determinants involved in hepadnaviral entry.World journal of gastroenterology · 2007Review
- Hepatitis B virus taxonomy and hepatitis B virus genotypes.World journal of gastroenterology · 2007Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
All hepadnaviruses known so far have a very limited host range, restricted to their natural hosts and a few closely related species. This is thought to be due mainly to sequence divergence in the large envelope protein and species-specific differences in host components essential for virus propagation. Here we report an infection of cranes with a novel hepadnavirus, designated CHBV, that has an unexpectedly broad host range and is only distantly evolutionarily related to avihepadnaviruses of related hosts. Direct DNA sequencing of amplified CHBV DNA as well a sequencing of cloned viral genomes revealed that CHBV is most closely related to, although distinct from, Ross' goose hepatitis B virus (RGHBV) and slightly less closely related to duck hepatitis B virus (DHBV). Phylogenetically, cranes are very distant from geese and ducks and are most closely related to herons and storks. Naturally occurring hepadnaviruses in the last two species are highly divergent in sequence from RGHBV and DHBV and do not infect ducks or do so only marginally. In contrast, CHBV from crane sera and recombinant CHBV produced from LMH cells infected primary duck hepatocytes almost as efficiently as DHBV did. This is the first report of a rather broad host range of an avihepadnavirus. Our data imply either usage of similar or identical entry pathways and receptors by DHBV and CHBV, unusual host and virus adaptation mechanisms, or divergent evolution of the host genomes and cellular components required for virus propagation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.