ArticleJournal of virology2003
Vigorous innate and virus-specific cytotoxic T-lymphocyte responses to murine cytomegalovirus in the submaxillary salivary gland.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 61 citations in OpenAlex.
- Leukotriene B4 regulates T cell recognition and control of MCMV in mucosal tissues.Mucosal immunology · 2025Article
- NK cells restrain cytotoxic CD8Science immunology · 2024Article
- Immune surveillance of cytomegalovirus in tissues.Cellular & molecular immunology · 2024Review
- Mucosal T-cell responses to chronic viral infections: Implications for vaccine design.Cellular & molecular immunology · 2024Review
- CD4 T Cell-Mediated Immune Control of Cytomegalovirus Infection in Murine Salivary Glands.Pathogens (Basel, Switzerland) · 2021Review
- Inhibitory Molecules PD-1, CD73 and CD39 Are Expressed by CD8Frontiers in immunology · 2021Article
- A Novel Experimental Approach forFrontiers in immunology · 2020Article
- Recent Advances in Mouse Models of Sjögren's Syndrome.Frontiers in immunology · 2020Review
- Salivary gland immunizationFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Lytic viral replication and immunopathology in a cytomegalovirus-induced mouse model of secondary hemophagocytic lymphohistiocytosis.Virology journal · 2017Article
- γδ T Cell-Mediated Immunity to Cytomegalovirus Infection.Frontiers in immunology · 2017Review
- Cytomegalovirus-Specific IL-10-Producing CD4+ T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence.PLoS pathogens · 2016Article
- Immunobiology of congenital cytomegalovirus infection of the central nervous system—the murine cytomegalovirus model.Cellular & molecular immunology · 2015Review
- Direct and Indirect Effects of Cytomegalovirus-Induced γδ T Cells after Kidney Transplantation.Frontiers in immunology · 2015Review
- Vaccination against a virus-encoded cytokine significantly restricts viral challenge.Journal of virology · 2013Article
- Article
- The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4⁺ and CD8⁺ T-cell immunity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Natural killer cells regulate murine cytomegalovirus-induced sialadenitis and salivary gland disease.Journal of virology · 2012Article
- Animal models in autoimmune diseases: lessons learned from mouse models for Sjögren's syndrome.Clinical reviews in allergy & immunology · 2012Review
- UNC93B1 mediates innate inflammation and antiviral defense in the liver during acute murine cytomegalovirus infection.PloS one · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
To better understand the immunological mechanisms that permit prolonged shedding of murine cytomegalovirus (MCMV) from the salivary gland, the phenotypic and functional characteristics of leukocytes infiltrating the submaxillary gland (SMG) were analyzed in infected BALB/c mice. A robust innate immune response, comprised of CD11c+ major histocompatibility complex class II+ CD11b- CD8alpha+ dendritic cells and gamma/delta T-cell receptor-bearing CD3+ T cells was prominent through at least 28 days postinfection. Concurrently, a dramatic increase in pan-NK (DX5+) CD3+ and CD8+ T cells was observed, while CD4+ T cells, known to be essential for viral clearance from this tissue, increased slightly. The expression particularly of gamma interferon but also of interleukin-10 and CC chemokines was extraordinarily high in the SMG in response to MCMV infection. The gamma interferon was produced primarily by CD4+ and CD8+ T lymphocytes and DX5+ CD3+ T cells. The SMG CD8+ T cells were highly cytolytic ex vivo, and a significant proportion of these cells were specific to an immunodominant MCMV peptide. These peptide-specific clones were not exhausted by the presence of high virus titers, which persisted in the SMG despite the strength of the cell-mediated responses. In contrast, MCMV replication was efficiently cleared from the draining cervical and periglandular lymph nodes, a tissue displaying a substantially weaker antiviral response. Our data indicated that vigorous innate and acquired immune responses are elicited, activated, and retained in response to mucosal inflammation from persistent MCMV infection of the submaxillary gland.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.