ArticleGenetics2002
A cluster of four receptor-like genes resides in the Vf locus that confers resistance to apple scab disease.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 84 citations in OpenAlex.
- Pear scab resistance gene Rvn1 from Ussurian pear is located in a cluster of receptor-like protein ethylene-inducing Xylanase (EIX) genes.BMC plant biology · 2025Article
- Rvi6-mediated defense mechanisms against apple scab.BMC plant biology · 2025Article
- Phenotyping, genetics, and "-omics" approaches to unravel and introgress enhanced resistance against apple scab (Horticulture research · 2024Article
- Chromosome-level phased genome assembly of "Antonovka" identified candidate apple scab-resistance genes highly homologous to HcrVf2 and HcrVf1 on linkage group 1.G3 (Bethesda, Md.) · 2023Article
- Sweet Immunity: The Effect of Exogenous Fructans on the Susceptibility of Apple (International journal of molecular sciences · 2020Article
- Characterisation of barley resistance to rhynchosporium on chromosome 6HS.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Article
- New biotechnological tools to accelerate scab-resistance trait transfer to apple.Genetics and molecular biology · 2017Article
- Article
- Multispectral airborne imagery in the field reveals genetic determinisms of morphological and transpiration traits of an apple tree hybrid population in response to water deficit.Journal of experimental botany · 2015Article
- Effector-triggered defence against apoplastic fungal pathogens.Trends in plant science · 2014Review
- The genetic structure of a Venturia inaequalis population in a heterogeneous host population composed of different Malus species.BMC evolutionary biology · 2013Article
- Functional analysis and expression profiling of HcrVf1 and HcrVf2 for development of scab resistant cisgenic and intragenic apples.Plant molecular biology · 2011Article
- Venturia inaequalis: the causal agent of apple scab.Molecular plant pathology · 2011Article
- Mining disease-resistance genes in roses: functional and molecular characterization of the rdr1 locus.Frontiers in plant science · 2011Article
- Candidate effector gene identification in the ascomycete fungal phytopathogen Venturia inaequalis by expressed sequence tag analysis.Molecular plant pathology · 2009Article
- The Venturia apple pathosystem: pathogenicity mechanisms and plant defense responses.Journal of biomedicine & biotechnology · 2009Review
- An overview of the apple genome through BAC end sequence analysis.Plant molecular biology · 2008Article
- Multiple models for Rosaceae genomics.Plant physiology · 2008Review
- Identification of functional apple scab resistance gene promoters.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2005Article
- The HcrVf2 gene from a wild apple confers scab resistance to a transgenic cultivated variety.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Vf locus, derived from the crabapple species Malus floribunda 821, confers resistance to five races of the fungal pathogen Venturia inaequalis, the causal agent of apple scab disease. In our previous research, the Vf locus was restricted to a BAC contig of approximately 290 kb covered by five overlapping BAC clones. Here, we report on cloning of the resistance gene(s) present in the Vf BAC contig using a highly reliable and straightforward approach. This approach relies on hybridization of labeled cDNAs to amplified inserts of subclones derived from BAC inserts, followed by recovery of full-size transcripts by rapid amplification of cDNA ends (RACE). A cluster of four resistance paralogs (Vfa1, Vfa2, Vfa3, and Vfa4) was identified in the Vf locus. Vfa1, Vfa2 and Vfa4 had no introns and are predicted to encode proteins characterized with extracellular leucine-rich repeats (LRRs) and transmembrane (TM) domains. However, Vfa3 contains an insertion of 780 bp at the end of the LRR motif, resulting in multiple truncated transcripts. Comparison of Vfa1, Vfa2, and Vfa4 paralogs revealed a high degree of overall homology in their deduced amino acid sequences, while divergences were mainly restricted within LRR domains, including variable LRR units, numerous amino acid substitutions, and several residue deletions/duplications. Differential expression profiles among the four paralogs were observed during leaf development. Vfa1, Vfa2, and Vfa3 were active in immature leaves, but slightly expressed in mature leaves, while Vfa4 was active in immature leaves and was highly expressed in mature leaves.
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