ArticleGenetics2002
Persistence of Mhc heterozygosity in homozygous clonal killifish, Rivulus marmoratus: implications for the origin of hermaphroditism.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Depletion of MHC supertype during domestication can compromise immunocompetence.Molecular ecology · 2021Article
- Comparative genomic analysis of inbred rat strains reveals the existence of ancestral polymorphisms.Mammalian genome : official journal of the International Mammalian Genome Society · 2020Article
- R-gene variation across Arabidopsis lyrata subspecies: effects of population structure, selection and mating system.BMC evolutionary biology · 2016Article
- Copy number variation and genetic diversity of MHC Class IIb alleles in an alien population of Xenopus laevis.Immunogenetics · 2015Article
- Evolutionary perspectives on clonal reproduction in vertebrate animals.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Balancing selection and the maintenance of MHC supertype variation in a selfing vertebrate.Proceedings. Biological sciences · 2013Article
- Maintenance of major histocompatibility supertype variation in selfing vertebrate is no evidence for overdominant selection.Proceedings. Biological sciences · 2013Article
- Maintaining functional major histocompatibility complex diversity under inbreeding: the case of a selfing vertebrate.Proceedings. Biological sciences · 2012Article
- The research of W.E. Mayer (1953-2012): a spectrum of immune systems.Immunogenetics · 2012Review
- Allard's argument versus Baker's contention for the adaptive significance of selfing in a hermaphroditic fish.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Article
- A molecule bearing an immunoglobulin-like V region of the CTX subfamily in amphioxus.Immunogenetics · 2003Article
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mangrove killifish Rivulus marmoratus, a neotropical fish in the order Cyprinodontiformes, is the only known obligatorily selfing, synchronous hermaphroditic vertebrate. To shed light on its population structure and the origin of hermaphroditism, major histocompatibility complex (Mhc) class I genes of the killifish from seven different localities in Florida, Belize, and the Bahamas were cloned and sequenced. Thirteen loci and their alleles were identified and classified into eight groups. The loci apparently arose approximately 20 million years ago (MYA) by gene duplications from a single common progenitor in the ancestors of R. marmoratus and its closest relatives. Distinct loci were found to be restricted to different populations and different individuals in the same population. Up to 44% of the fish were heterozygotes at Mhc loci, as compared to near homozygosity at non-Mhc loci. Large genetic distances between some of the Mhc alleles revealed the presence of ancestral allelic lineages. Computer simulation designed to explain these findings indicated that selfing is incomplete in R. marmoratus populations, that Mhc allelic lineages must have diverged before the onset of selfing, and that the hermaphroditism arose in a population containing multiple ancestral Mhc lineages. A model is proposed in which hermaphroditism arose stage-wise by mutations, each of which spread through the entire population and was fixed independently in the emerging clones.
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