ArticleGenetics2002
Molecular population genetics of Xdh and the evolution of base composition in Drosophila.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Nucleosomes shape DNA polymorphism and divergence.PLoS genetics · 2014Article
- Drosophila americana as a model species for comparative studies on the molecular basis of phenotypic variation.Genome biology and evolution · 2013Article
- Population genomic analysis of base composition evolution in Drosophila melanogaster.Genome biology and evolution · 2012Article
- Article
- Population genomics: whole-genome analysis of polymorphism and divergence in Drosophila simulans.PLoS biology · 2007Article
- Article
- Reduced selection for codon usage bias in Drosophila miranda.Journal of molecular evolution · 2007Article
- Transition-transversion bias is not universal: a counter example from grasshopper pseudogenes.PLoS genetics · 2007Article
- Strong regional heterogeneity in base composition evolution on the Drosophila X chromosome.Genetics · 2006Article
- Molecular population genetics of accessory gland protein genes and testis-expressed genes in Drosophila mojavensis and D. arizonae.Genetics · 2005Article
- Patterns of selection on synonymous and nonsynonymous variants in Drosophila miranda.Genetics · 2005Article
- Patterns of evolutionary constraints in intronic and intergenic DNA of Drosophila.Genome research · 2004Article
- A new Drosophila spliceosomal intron position is common in plants.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Few loci have been measured for DNA polymorphism and divergence in several species. Here we report such data from the protein-coding region of xanthine dehydrogenase (Xdh) in 22 species of Drosophila. Many of our samples were from closely related species, allowing us to confidently assign substitutions to individual lineages. Surprisingly, Xdh appears to be fixing more A/T mutations than G/C mutations in most lineages, leading to evolution of higher A/T content in the recent past. We found no compelling evidence for selection on protein variation, though some aspects of the data support the notion that a significant fraction of amino acid polymorphisms are slightly deleterious. Finally, we found no convincing evidence that levels of silent heterozygosity are associated with rates of protein evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.