ArticleGenetics2002
A cuticle collagen encoded by the lon-3 gene may be a target of TGF-beta signaling in determining Caenorhabditis elegans body shape.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- Mitochondrial redox homeostasis links organellar stress surveillance to germline and somatic integrity in Caenorhabditis elegans.Redox biology · 2026Article
- The C. elegans LON-1 protein requires its CAP domain for function in regulating body size and BMP signaling.Genetics · 2025Article
- Article
- Genome-wide analysis of Smad and Schnurri transcription factors inbioRxiv : the preprint server for biology · 2025Article
- The Caenorhabditis elegans cuticle and precuticle: a model for studying dynamic apical extracellular matrices in vivo.Genetics · 2024Review
- Nanoscale patterning of collagens in C. elegans apical extracellular matrix.Nature communications · 2023Article
- Signaling circuits and the apical extracellular matrix in aging: connections identified in the nematodeAmerican journal of physiology. Cell physiology · 2023Review
- Reciprocal interactions between transforming growth factor beta signaling and collagens: Insights from Caenorhabditis elegans.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- Review
- Molecular Effects of Silver Nanoparticles on Monogenean Parasites: Lessons fromInternational journal of molecular sciences · 2020Article
- BMP Signaling Determines Body Size via Transcriptional Regulation of Collagen Genes inGenetics · 2018Article
- Multiple Mechanisms Inactivate the LIN-41 RNA-Binding Protein To Ensure a Robust Oocyte-to-Embryo Transition inGenetics · 2018Article
- Dramatic evolution of body length due to postembryonic changes in cell size in a newly discovered close relative ofEvolution letters · 2018Article
- High-throughput screens using photo-highlighting discover BMP signaling in mitochondrial lipid oxidation.Nature communications · 2017Article
- Promotion of bone morphogenetic protein signaling by tetraspanins and glycosphingolipids.PLoS genetics · 2015Article
- Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity.Nature · 2015Article
- Proteomic profile of Ortleppascaris sp.: A helminth parasite of Rhinella marina in the Amazonian region.International journal for parasitology. Parasites and wildlife · 2014Article
- TGF-β signaling in C. elegans.WormBook : the online review of C. elegans biology · 2013Review
- Regulation of fertility, survival, and cuticle collagen function by the Caenorhabditis elegans eaf-1 and ell-1 genes.The Journal of biological chemistry · 2011Article
- C. elegans ADAMTS ADT-2 regulates body size by modulating TGFβ signaling and cuticle collagen organization.Developmental biology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The signaling pathway initiated by the TGF-beta family member DBL-1 in Caenorhabditis elegans controls body shape in a dose-dependent manner. Loss-of-function (lf) mutations in the dbl-1 gene cause a short, small body (Sma phenotype), whereas overexpression of dbl-1 causes a long body (Lon phenotype). To understand the cellular mechanisms underlying these phenotypes, we have isolated suppressors of the Sma phenotype resulting from a dbl-1(lf) mutation. Two of these suppressors are mutations in the lon-3 gene, of which four additional alleles are known. We show that lon-3 encodes a collagen that is a component of the C. elegans cuticle. Genetic and reporter-gene expression analyses suggest that lon-3 is involved in determination of body shape and is post-transcriptionally regulated by the dbl-1 pathway. These results support the possibility that TGF-beta signaling controls C. elegans body shape by regulating cuticle composition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.