ArticleBiophysical journal2003
The control of seizure-like activity in the rat hippocampal slice.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- High and Low-Frequency Stimulation Effect on Epileptiform Activity in Brain Slices.Medical journal of the Islamic Republic of Iran · 2023Article
- Dynamiceuticals: The Next Stage in Personalized Medicine.Frontiers in neuroscience · 2017Article
- Critical review of the responsive neurostimulator system for epilepsy.Medical devices (Auckland, N.Z.) · 2015Review
- Long-lasting hyperpolarization underlies seizure reduction by low frequency deep brain electrical stimulation.The Journal of physiology · 2013Article
- Seizures as imbalanced up states: excitatory and inhibitory conductances during seizure-like events.Journal of neurophysiology · 2013Article
- Fiber tract stimulation can reduce epileptiform activity in an in-vitro bilateral hippocampal slice preparation.Experimental neurology · 2013Article
- Controlling seizure-like events by perturbing ion concentration dynamics with periodic stimulation.PloS one · 2013Article
- Wavelet-based Gaussian-mixture hidden Markov model for the detection of multistage seizure dynamics: a proof-of-concept study.Biomedical engineering online · 2011Article
- A brain slice culture model of viral encephalitis reveals an innate CNS cytokine response profile and the therapeutic potential of caspase inhibition.Experimental neurology · 2011Article
- Toward rational design of electrical stimulation strategies for epilepsy control.Epilepsy & behavior : E&B · 2010Review
- Treating epilepsy via adaptive neurostimulation: a reinforcement learning approach.International journal of neural systems · 2009Article
- Transition to seizures in the isolated immature mouse hippocampus: a switch from dominant phasic inhibition to dominant phasic excitation.The Journal of physiology · 2008Article
- Interneuron and pyramidal cell interplay during in vitro seizure-like events.Journal of neurophysiology · 2006Article
- Enhanced synchrony in epileptiform activity? Local versus distant phase synchronization in generalized seizures.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Article
- Mechanisms of Neurostimulation for Epilepsy.Epilepsy currentsArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sudden and transient hypersynchrony of neuronal firing that characterizes epileptic seizures can be considered as the transitory stabilization of metastable states present within the dynamical repertoire of a neuronal network. Using an in vitro model of recurrent spontaneous seizures in the rat horizontal hippocampal slice preparation, we present an approach to characterize the dynamics of the transition to seizure, and to use this information to control the activity and avoid the occurrence of seizure-like events. The transition from the interictal activity (between seizures) to the seizure-like event is aborted by brief (20-50 s) low-frequency (0.5 Hz) periodic forcing perturbations, applied via an extracellular stimulating electrode to the mossy fibers, the axons of the dentate neurons that synapse onto the CA3 pyramidal cells. This perturbation results in the stabilization of an interictal-like low-frequency firing pattern in the hippocampal slice. The results derived from this work shed light on the dynamics of the transition to seizure and will further the development of algorithms that can be used in automated devices to stop seizure occurrence.
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