ArticleBiophysical journal2003
Modulation of nuclear pore topology by transport modifiers.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Permeability-Based Measurement of Nanobody Binding to Nuclear Pore Complexes by Transient Scanning Electrochemical Microscopy.Analytical chemistry · 2026Article
- Karyopherins remodel the dynamic organization of the nuclear pore complex transport barrier.Nature cell biology · 2025Article
- Molecular insights into the effect of 1,6-hexanediol on FUS phase separation.The EMBO journal · 2025Article
- Nanoscale Hydrophobicity of Transport Barriers in the Nuclear Pore Complex as Compared with the Liquid/Liquid Interface by Scanning Electrochemical Microscopy.Analytical chemistry · 2025Article
- Nanoscale Quantitative Imaging of Single Nuclear Pore Complexes by Scanning Electrochemical Microscopy.Analytical chemistry · 2024Article
- A survey of the specificity and mechanism of 1,6 hexanediol-induced disruption of nuclear transport.Nucleus (Austin, Tex.) · 2023Article
- Unveiling the complexity: assessing models describing the structure and function of the nuclear pore complex.Frontiers in cell and developmental biology · 2023Review
- Evolution and diversification of the nuclear pore complex.Biochemical Society transactions · 2021Review
- Physics of the Nuclear Pore Complex: Theory, Modeling and Experiment.Physics reports · 2021Article
- Nanoscale electrostatic gating of molecular transport through nuclear pore complexes as probed by scanning electrochemical microscopy.Chemical science · 2019Article
- Probing High Permeability of Nuclear Pore Complexes by Scanning Electrochemical Microscopy: CaAnalytical chemistry · 2019Article
- Insights into the gate of the nuclear pore complex.Nucleus (Austin, Tex.) · 2016Article
- Nanoscale stiffness topography reveals structure and mechanics of the transport barrier in intact nuclear pore complexes.Nature nanotechnology · 2015Article
- Calcium regulation of nucleocytoplasmic transport.Protein & cell · 2011Review
- Nuclear import of an intact preassembled proteasome particle.Molecular biology of the cell · 2011Article
- Transportin mediates nuclear entry of DNA in vertebrate systems.Traffic (Copenhagen, Denmark) · 2009Article
- Towards reconciling structure and function in the nuclear pore complex.Histochemistry and cell biology · 2008Review
- Biology and biophysics of the nuclear pore complex and its components.International review of cell and molecular biology · 2008Review
- Ethanol alters access to the cell nucleus.Pflugers Archiv : European journal of physiology · 2007Article
- Route of glucocorticoid-induced macromolecules across the nuclear envelope as viewed by atomic force microscopy.Pflugers Archiv : European journal of physiology · 2006Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nuclear pore complex (NPC) represents the only pathway for macromolecular communication between the nuclear and cytoplasmic compartments of the cell. Nucleocytoplasmic transport requires the interaction of transport receptors with phenylalanine-glycine (FG)-repeats that line the transport pathway through the NPC. Here we examine the effects of transport receptors and amphipathic alcohols on NPC topology using scanning force microscopy. We show that transport receptors that irreversibly bind FG-repeats increase NPC vertical aspect, whereas transport receptors that weakly interact with FG-repeats increase NPC diameter. Interestingly, small polar alcohols likewise increase NPC diameter. These opposing effects agree with the inhibition or enhancement of nuclear transport, respectively, previously ascribed to these agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.