ArticleBiophysical journal2003
Parallel microchannel-based measurements of individual erythrocyte areas and volumes.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 102 citations in OpenAlex.
- Cortical OProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Recent advances in microscale techniques for red blood cells manipulation.Biomicrofluidics · 2025Review
- Red blood cell passage through deformable interendothelial slits in the spleen: Insights into splenic filtration and hemodynamics.Computers in biology and medicine · 2024Article
- Biomechanics of phagocytosis of red blood cells by macrophages in the human spleen.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Physical mechanisms of red blood cell splenic filtration.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Significance of two transmembrane ion gradients for human erythrocyte volume stabilization.PloS one · 2022Article
- Structural and mechanical properties of the red blood cell's cytoplasmic membrane seen through the lens of biophysics.Frontiers in physiology · 2022Review
- How the spleen reshapes and retains young and old red blood cells: A computational investigation.PLoS computational biology · 2021Article
- Surface area-to-volume ratio, not cellular viscoelasticity, is the major determinant of red blood cell traversal through small channels.Cellular microbiology · 2021Article
- Theoretical Bases for the Role of Red Blood Cell Shape in the Regulation of Its Volume.Frontiers in physiology · 2020Review
- Multimodal analysis of Plasmodium knowlesi-infected erythrocytes reveals large invaginations, swelling of the host cell, and rheological defects.Cellular microbiology · 2019Article
- A Model of Piezo1-Based Regulation of Red Blood Cell Volume.Biophysical journal · 2019Article
- Continuous Change in Membrane and Membrane-Skeleton Organization During Development From Proerythroblast to Senescent Red Blood Cell.Frontiers in physiology · 2018Review
- Erythrocyte β spectrin can be genetically targeted to protect mice from malaria.Blood advances · 2017Article
- Washing in hypotonic saline reduces the fraction of irreversibly-damaged cells in stored blood: a proof-of-concept study.Blood transfusion = Trasfusione del sangue · 2017Article
- An On-Chip RBC Deformability Checker Significantly Improves Velocity-Deformation Correlation.Micromachines · 2016Article
- Biomechanics of red blood cells in human spleen and consequences for physiology and disease.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- High-Throughput Assessment of Cellular Mechanical Properties.Annual review of biomedical engineering · 2015Review
- A microfluidic platform for profiling biomechanical properties of bacteria.Lab on a chip · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe a microchannel device which utilizes a novel approach to obtain area and volume measurements on many individual red blood cells. Red cells are aspirated into the microchannels much as a single red blood cell is aspirated into a micropipette. Inasmuch as there are thousands of identical microchannels with defined geometry, data for many individual red cells can be rapidly acquired, and the fundamental heterogeneity of cell membrane biophysics can be analyzed. Fluorescent labels can be used to quantify red cell surface and cytosolic features of interest simultaneously with the measurement of area and volume for a given cell. Experiments that demonstrate and evaluate the microchannel measuring capabilities are presented and potential improvements and extensions are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.