ArticleBiophysical journal2003
Sequence-dependent DNA condensation and the electrostatic zipper.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 74 citations in OpenAlex.
- Alexidine, identified as a Z-DNA inducer by the NanoZ screening platform, acts as a transcriptional regulator.Nucleic acids research · 2026Article
- Article
- New Insights into the Role of Ligand-Binding Modes in GC-DNA Condensation through Thermodynamic and Spectroscopic Studies.ACS omega · 2023Article
- A Comprehensive Biophysical Analysis of the Effect of DNA Binding Drugs on Protamine-induced DNA Condensation.Scientific reports · 2019Article
- A Sequence-Dependent DNA Condensation Induced by Prion Protein.Journal of nucleic acids · 2018Article
- Role of Disulfide Bonds on DNA Packaging Forces in Bull Sperm Chromatin.Biophysical journal · 2017Article
- Dynamic response of HPV16/anti-HPV16 pairs with unbinding events studied by atomic force microscopy.Biochemistry and biophysics reports · 2016Article
- DNA methylation effects on tetra-nucleosome compaction and aggregation.Biophysical journal · 2014Article
- Chiroptical detection of condensed nickel(II)-Z-DNA in the presence of the B-DNA via porphyrin exciton coupled circular dichroism.The journal of physical chemistry. B · 2011Article
- Carbon nanotubes selective destabilization of duplex and triplex DNA and inducing B-A transition in solution.Nucleic acids research · 2006Article
- Ligand-induced DNA condensation: choosing the model.Biophysical journal · 2005Article
- Contribution of hydrophobicity to thermodynamics of ligand-DNA binding and DNA collapse.Biophysical journal · 2005Article
- Extended, relaxed, and condensed conformations of hyaluronan observed by atomic force microscopy.Biophysical journal · 2005Article
- Formation of DNA nanoparticles in the presence of novel polyamine analogues: a laser light scattering and atomic force microscopic study.Nucleic acids research · 2004Article
- Adsorption of DNA to mica mediated by divalent counterions: a theoretical and experimental study.Biophysical journal · 2003Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sequence-dependent configuration changes and condensation of double-stranded poly(dG-dC).(dG-dC) (GC-DNA) and ds poly(dA-dT).(dA-dT) (AT-DNA) were observed by atomic force microscopy in the presence of Ni(II). Less condensing agent was required to generate configuration changes in GC-DNA as compared to AT-DNA. In the presence of Ni(II) cations, GC-DNA adopted a Z-type conformation and underwent a stepwise condensation, starting with partial intramolecular folding, followed by intermolecular condensation of two to several molecules and ending with the formation of toroids, rods, and jumbles. GC-DNA condensates were unusual in that the most highly condensed regions were surrounded by loops of ds GC-DNA. In contrast, AT-DNA retained its B-type conformation and displayed only minor condensation even at high Ni(II) concentrations. The Ni(II)-dependent differences in condensation between GC-DNA and AT-DNA are predicted by an extension of the electrostatic zipper motif proposed by Kornyshev and Leikin, in which we account for shorter than Debye screening length surface separations between the DNA molecules and for the Ni(II)-induced conformation change of GC-DNA to Z-DNA.
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