ArticleBiophysical journal2003
Lowering the barriers to random walks on the cell surface.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Cytokines Induce Faster Membrane Diffusion of MHC Class I and the Ly49A Receptor in a Subpopulation of Natural Killer Cells.Frontiers in immunology · 2016Article
- Regulation from within: the cytoskeleton in transmembrane signaling.Trends in cell biology · 2012Review
- Monitoring the size and lateral dynamics of ErbB1 enriched membrane domains through live cell plasmon coupling microscopy.PloS one · 2012Article
- Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment.The Journal of cell biology · 2010Article
- Quantitative understanding of cell signaling: the importance of membrane organization.Current opinion in biotechnology · 2010Review
- The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor.Immunity · 2010Article
- Time series analysis of particle tracking data for molecular motion on the cell membrane.Bulletin of mathematical biology · 2009Article
- Increased mobility of major histocompatibility complex I-peptide complexes decreases the sensitivity of antigen recognition.The Journal of biological chemistry · 2008Article
- Actin restricts FcepsilonRI diffusion and facilitates antigen-induced receptor immobilization.Nature cell biology · 2008Article
- High-Resolution Models of Motion of Macromolecules in Cell Membranes.Mathematics and computers in simulation · 2008Article
- Single-particle tracking of membrane protein diffusion in a potential: simulation, detection, and application to confined diffusion of CFTR Cl- channels.Biophysical journal · 2007Article
- Sources of anomalous diffusion on cell membranes: a Monte Carlo study.Biophysical journal · 2007Article
- Altered membrane dynamics of quantum dot-conjugated integrins during osteogenic differentiation of human bone marrow derived progenitor cells.Biophysical journal · 2007Article
- Spatial regulation and the rate of signal transduction activation.PLoS computational biology · 2006Article
- Revealing the topography of cellular membrane domains by combined atomic force microscopy/fluorescence imaging.Biophysical journal · 2006Article
- Persistence of zinc-binding bacterial superantigens at the surface of antigen-presenting cells contributes to the extreme potency of these superantigens as T-cell activators.Infection and immunity · 2005Article
- Cholesterol dictates the freedom of EGF receptors and HER2 in the plane of the membrane.Biophysical journal · 2005Article
- Local mobility in lipid domains of supported bilayers characterized by atomic force microscopy and fluorescence correlation spectroscopy.Biophysical journal · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We used fluorescence recovery after photobleaching (FRAP) and single particle tracking (SPT) techniques to compare diffusion of class I major histocompatibility complex molecules (MHC) on normal and alpha-spectrin-deficient murine erythroleukemia (MEL) cells. Because the cytoskeleton mesh acts as a barrier to lateral mobility of membrane proteins, we expected that diffusion of membrane proteins in alpha-spectrin-deficient MEL cells would differ greatly from that in normal MEL cells. In the event, diffusion coefficients derived from either FRAP or SPT analysis were similar for alpha-spectrin-deficient and normal MEL cells, differing by a factor of approximately 2, on three different timescales: tens of seconds, 1-10 s, and 100 ms. SPT analysis showed that the diffusion of most class I MHC molecules was confined on both cell types. On the normal MEL cells, the mean diagonal length of the confined area was 330 nm with a mean residency time of 40s. On the alpha-spectrin-deficient MEL cells, the mean diagonal length was 650 nm with a mean residency time of 45s. Thus there are fewer barriers to lateral diffusion on cytoskeleton mutant MEL cells than on normal MEL cells, but this difference does not strongly affect lateral diffusion on the scales measured here.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.