ArticleBiophysical journal2003
A model of the oscillatory metabolism of activated neutrophils.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 73 citations in OpenAlex.
- Missing data in amortized simulation-based neural posterior estimation.PLoS computational biology · 2024Article
- Parameter estimation in models of biological oscillators: an automated regularised estimation approach.BMC bioinformatics · 2019Article
- Computational Models of Reactive Oxygen Species as Metabolic Byproducts and Signal-Transduction Modulators.Frontiers in pharmacology · 2016Review
- Time and Demand are Two Critical Dimensions of Immunometabolism: The Process of Macrophage Activation and the Pentose Phosphate Pathway.Frontiers in immunology · 2015Review
- Reaction-diffusion systems in intracellular molecular transport and control.Angewandte Chemie (International ed. in English) · 2010Review
- Imaging enzymes at work: metabolic mapping by enzyme histochemistry.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2010Review
- Novel role for aldose reductase in mediating acute inflammatory responses in the lung.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- A method for determining the robustness of bio-molecular oscillator models.BMC systems biology · 2009Article
- Using chemical organization theory for model checking.Bioinformatics (Oxford, England) · 2009Article
- Elevated glucose concentrations promote receptor-independent activation of adherent human neutrophils: an experimental and computational approach.Biophysical journal · 2007Article
- Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis.Arthritis research & therapy · 2006Article
- Electron and proton transport by NADPH oxidases.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Review
- Ion channel clustering enhances weak electric field detection by neutrophils: apparent roles of SKF96365-sensitive cation channels and myeloperoxidase trafficking in cellular responses.European biophysics journal : EBJ · 2005Article
- Transition from stochastic to deterministic behavior in calcium oscillations.Biophysical journal · 2005Article
- Voltage- and NADPH-dependence of electron currents generated by the phagocytic NADPH oxidase.The Biochemical journal · 2005Article
- TLR4 mediates human retinal pigment epithelial endotoxin binding and cytokine expression.Transactions of the American Ophthalmological Society · 2005Article
- Toll-like receptor 4 (TLR4) of retinal pigment epithelial cells participates in transmembrane signaling in response to photoreceptor outer segments.The Journal of general physiology · 2004Article
- Fluorescence spectroscopic detection of mitochondrial flavoprotein redox oscillations and transient reduction of the NADPH oxidase-associated flavoprotein in leukocytes.European biophysics journal : EBJ · 2004Article
- Concerted simulations reveal how peroxidase compound III formation results in cellular oscillations.Biophysical journal · 2003Article
- Pregnancy alters glucose-6-phosphate dehydrogenase trafficking, cell metabolism, and oxidant release of maternal neutrophils.The Journal of clinical investigation · 2002Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
We present a two-compartment model to explain the oscillatory behavior observed experimentally in activated neutrophils. Our model is based mainly on the peroxidase-oxidase reaction catalyzed by myeloperoxidase with melatonin as a cofactor and NADPH oxidase, a major protein in the phagosome membrane of the leukocyte. The model predicts that after activation of a neutrophil, an increase in the activity of the hexose monophosphate shunt and the delivery of myeloperoxidase into the phagosome results in oscillations in oxygen and NAD(P)H concentration. The period of oscillation changes from >200 s to 10-30 s. The model is consistent with previously reported oscillations in cell metabolism and oxidant production. Key features and predictions of the model were confirmed experimentally. The requirement of the hexose monophosphate pathway for 10 s oscillations was verified using 6-aminonicotinamide and dexamethasone, which are inhibitors of glucose-6-phosphate dehydrogenase. The role of the NADPH oxidase in promoting oscillations was confirmed by dose-response studies of the effect of diphenylene iodonium, an inhibitor of the NADPH oxidase. Moreover, the model predicted an increase in the amplitude of NADPH oscillations in the presence of melatonin, which was confirmed experimentally. Successful computer modeling of complex chemical dynamics within cells and their chemical perturbation will enhance our ability to identify new antiinflammatory compounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.