ArticleBiophysical journal2003
On the role of stochastic channel behavior in intracellular Ca2+ dynamics.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
- Stochastic model of IP3-induced Ca2+ spiking of HEK293 cells.PLoS computational biology · 2025Article
- Modeling IPBiophysical journal · 2023Article
- Close agreement between deterministic versus stochastic modeling of first-passage time to vesicle fusion.Biophysical journal · 2022Article
- Kramers Rate Theory of Pacemaker Dynamics in Noisy Excitable Media.Physical review letters · 2022Article
- Stationary CaBiophysical journal · 2021Article
- Efficient Approximations for Stationary Single-Channel CaBiophysical journal · 2020Article
- Extension of Rapid Buffering Approximation to CaBiophysical journal · 2018Article
- Computational Model of Calcium Signaling in Cardiac Atrial Cells at the Submicron Scale.Frontiers in physiology · 2018Article
- IPCellular and molecular life sciences : CMLS · 2017Review
- A Bayesian approach to modelling heterogeneous calcium responses in cell populations.PLoS computational biology · 2017Article
- A mathematical model of calcium dynamics in HSY cells.PLoS computational biology · 2017Article
- Stochastic initiation and termination of calcium-mediated triggered activity in cardiac myocytes.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Diversity of Evoked Astrocyte CaFrontiers in systems neuroscience · 2017Article
- Calcium waves in a grid of clustered channels with synchronous IPThe European physical journal. E, Soft matter · 2016Article
- Padé Approximation of a Stationary Single-Channel CaBiophysical journal · 2016Article
- Long-Lasting Sparks: Multi-Metastability and Release Competition in the Calcium Release Unit Network.PLoS computational biology · 2016Article
- Exact stochastic simulation of a calcium microdomain reveals the impact of Ca²⁺ fluctuations on IP₃R gating.Biophysical journal · 2015Article
- Modulation of elementary calcium release mediates a transition from puffs to waves in an IP3R cluster model.PLoS computational biology · 2015Article
- Nonlinear and Stochastic Dynamics in the Heart.Physics reports · 2014Article
- Basis for a neuronal version of Grover's quantum algorithm.Frontiers in molecular neuroscience · 2014Article
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1 author.
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Abstract
I present a stochastic model for intracellular Ca(2+) oscillations. The model starts from stochastic binding and dissociation of Ca(2+) to binding sites on a single subunit of the IP(3)-receptor channel but is capable of simulating large numbers of clusters for many oscillation periods too. I find oscillations with variable periods ranging from 17 s to 120 s and a standard deviation well in the experimentally observed range. Long period oscillations can be perceived as nucleation phenomenon and can be observed for a large variety of single channel dynamics. Their period depends on the geometric characteristics of the cluster array. Short periods are in the range of the time scale of channel dynamics. Both long and short period oscillations occur for parameters with a nonoscillatory deterministic regime.
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