ArticleBiophysical journal2003
Buffers and oscillations in intracellular Ca2+ dynamics.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 99 citations in OpenAlex.
- Greater amount of visual feedback decreases force variability by reducing force oscillations from 0-1 and 3-7 Hz.European journal of applied physiology · 2010Trial
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- Cross Talking Calcium, IPCell biochemistry and biophysics · 2024Article
- Modelling Cross Talk in the Spatiotemporal System Dynamics of Calcium, IPCell biochemistry and biophysics · 2024Article
- Study of disorders in regulatory spatiotemporal neurodynamics of calcium and nitric oxide.Cognitive neurodynamics · 2023Article
- Spatio temporal interdependent calcium and buffer dynamics regulating DAG in a hepatocyte cell due to obesity.Journal of bioenergetics and biomembranes · 2023Article
- Mechanistic insights of neuronal calcium and IPEuropean biophysics journal : EBJ · 2023Article
- Effect of disturbances in neuronal calcium and IP3 dynamics on β-amyloid production and degradation.Cognitive neurodynamics · 2023Article
- Stationary CaBiophysical journal · 2021Article
- Efficient Approximations for Stationary Single-Channel CaBiophysical journal · 2020Article
- Simulation of calcium signaling in fine astrocytic processes: Effect of spatial properties on spontaneous activity.PLoS computational biology · 2019Article
- Extension of Rapid Buffering Approximation to CaBiophysical journal · 2018Article
- Padé Approximation of a Stationary Single-Channel CaBiophysical journal · 2016Article
- Article
- The influence of Ca²⁺ buffers on free [Ca²⁺] fluctuations and the effective volume of Ca²⁺ microdomains.Biophysical journal · 2014Article
- Do calcium buffers always slow down the propagation of calcium waves?Journal of mathematical biology · 2013Article
- Intracellular signaling by diffusion: can waves of hydrogen peroxide transmit intracellular information in plant cells?Frontiers in plant science · 2012Article
- Unitary Ca(2+) current through recombinant type 3 InsP(3) receptor channels under physiological ionic conditions.The Journal of general physiology · 2010Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
I model the behavior of intracellular Ca(2+) release with high buffer concentrations. The model uses a spatially discrete array of channel clusters. The channel subunit dynamics is a stochastic representation of the DeYoung-Keizer model. The calculations show that the concentration profile of fast buffer around an open channel is more localized than that of slow buffers. Slow buffers allow for release of larger amounts of Ca(2+) from the endoplasmic reticulum and hence bind more Ca(2+) than fast buffers with the same dissociation constant and concentration. I find oscillation-like behavior for high slow buffer concentration and low Ca(2+) content of the endoplasmic reticulum. High concentration of slow buffer leads to oscillation-like behavior by repetitive wave nucleation for high Ca(2+) content of the endoplasmic reticulum. Localization of Ca(2+) release by slow buffer, as used in experiments, can be reproduced by the modeling approach.
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