ArticleBritish journal of pharmacology2003
Demonstration of functional M3-muscarinic receptors in ventricular cardiomyocytes of adult rats.
Article in British journal of pharmacology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
- Evaluation of Potential Molecular Targets of the Alkaloid Epiisopiloturine, Involved in Cardioprotective Effects, Using Computational Molecular Docking in an Animal Model of Cardiac Ischemia and Reperfusion.International journal of molecular sciences · 2025Article
- Further investigations on the influence of protein phosphatases on the signaling of muscarinic receptors in the atria of mouse hearts.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Activation of the nonneuronal cholinergic cardiac system by hypoxic preconditioning protects isolated adult cardiomyocytes from hypoxia/reoxygenation injury.American journal of physiology. Heart and circulatory physiology · 2024Article
- Multiplexed Optical Sensors in Arrayed Islands of Cells for multimodal recordings of cellular physiology.Nature communications · 2020Article
- Suppression of cardiomyocyte functions by β-CTX isolated from the Thai king cobra (The journal of venomous animals and toxins including tropical diseases · 2020Article
- Choline Attenuates Cardiac Fibrosis by Inhibiting p38MAPK Signaling Possibly by Acting on MFrontiers in pharmacology · 2019Article
- G-Protein-Coupled Receptors in Heart Disease.Circulation research · 2018Review
- Cholinergic activity as a new target in diseases of the heart.Molecular medicine (Cambridge, Mass.) · 2015Review
- An inotropic action caused by muscarinic receptor subtype 3 in canine cardiac purkinje fibers.ISRN pharmacology · 2013Article
- Cardiac effects of muscarinic receptor antagonists used for voiding dysfunction.British journal of clinical pharmacology · 2011Review
- Overexpression of M₃ muscarinic receptor is a novel strategy for preventing sudden cardiac death in transgenic mice.Molecular medicine (Cambridge, Mass.) · 2011Article
- M3 muscarinic receptors mediate positive inotropic responses in mouse atria: a study with muscarinic receptor knockout mice.The Journal of pharmacology and experimental therapeutics · 2009Article
- Role of M3 receptor in aconitine/barium-chloride-induced preconditioning against arrhythmias in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2009Article
- Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation.British journal of pharmacology · 2009Article
- Hawthorn (Crataegus monogyna Jacq.) extract exhibits atropine-sensitive activity in a cultured cardiomyocyte assay.Journal of natural medicines · 2009Article
- The detection of the non-M2 muscarinic receptor subtype in the rat heart atria and ventricles.Naunyn-Schmiedeberg's archives of pharmacology · 2008Article
- Muscarinic receptors: their distribution and function in body systems, and the implications for treating overactive bladder.British journal of pharmacology · 2006Review
- In vivo antimuscarinic actions of the third generation antihistaminergic agent, desloratadine.BMC pharmacology · 2005Article
- Functional M3 muscarinic acetylcholine receptors in mammalian hearts.British journal of pharmacology · 2004Review
- Existence of functional M3-muscarinic receptors in the human heart.Naunyn-Schmiedeberg's archives of pharmacology · 2003Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1 Muscarinic receptors (M-receptors) in the mammalian heart are predominantly of the M(2)-subtype. The aim of this study was to find out whether there might exist an additional myocardial non-M(2)-receptor. 2 For this purpose, we assessed, in adult rat isolated ventricular cardiomyocytes, carbachol-induced [(3)H]-inositol phosphate (IP) formation, and its inhibition by M-receptor antagonists. 3 Carbachol (10(-7)-10(-3) mol l(-1)) increased IP-formation (maximal increase: 14+/-3% above basal, n=6). This increase was significantly enhanced by pretreatment with pertussis toxin (PTX, 250 ng ml(-1) for 20 h): maximal increase was 31+/-5%, pEC(50)-value was 5.08+/-0.33 (n=6). 4 In PTX-pretreated cardiomyocytes 100 micromol l(-1) carbachol-induced IP-formation was inhibited by atropine (pK(i)-value: 8.89+/-0.10) and by the M(3)-receptor antagonist darifenacin (pK(i)-value: 8.67+/-0.23) but was not significantly affected by the M(1)-receptor antagonist pirenzepine (1 micromol l(-1)) or the M(2)-receptor antagonists AF-DX 116 and himbacine (1 micromol l(-1)). 5 In conclusion, in adult rat cardiomyocytes there exists an additional, non-M(2)-receptor, that is coupled to activation of the phospholipase C/IP(3)-pathway; this receptor is very likely of the M(3)-subtype.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.