ArticleClinical and diagnostic laboratory immunology2003
Keratinocyte expression of human beta defensin 2 following bacterial infection: role in cutaneous host defense.
Article in Clinical and diagnostic laboratory immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 82 citations in OpenAlex.
- Impact of newborn skin-cleansing with chlorhexidine on neonatal mortality in southern Nepal: a community-based, cluster-randomized trial.Pediatrics · 2007Trial
- Induction of Human β-Defensin-2 by VaginalOpen forum infectious diseases · 2026Article
- Antimicrobial Peptides Against Antimicrobial-Resistant Bacteria: Focus on Machine Learning.Infection and drug resistance · 2026Review
- Regulation of antimicrobial peptides in Hermetia illucens in response to fungal exposure.Scientific reports · 2024Article
- Molecular Mechanisms of Bacterial Resistance to Antimicrobial Peptides in the Modern Era: An Updated Review.Microorganisms · 2024Review
- Towards sustainable antimicrobial therapies forSustainable microbiology · 2024Review
- Detection of Antimicrobial Peptides in Stratum Corneum by Mass Spectrometry.International journal of molecular sciences · 2021Article
- Controlling the Growth of the Skin Commensal Staphylococcus epidermidis Using d-Alanine Auxotrophy.mSphere · 2020Article
- Human Defensins: A Novel Approach in the Fight against Skin ColonizingAntibiotics (Basel, Switzerland) · 2020Review
- Molecular Profiling of Keratinocyte Skin Tumors LinksCancers · 2020Article
- Histological and immunological characteristics of the junctional epithelium.The Japanese dental science review · 2018Review
- Topographical diversity of common skin microflora and its association with skin environment type: An observational study in Chinese women.Scientific reports · 2017Observational
- Derivation of marker gene signatures from human skin and their use in the interpretation of the transcriptional changes associated with dermatological disorders.The Journal of pathology · 2017Article
- Endogenous Antimicrobial Peptide Expression in Response to Bacterial Epidermal Colonization.Frontiers in immunology · 2017Review
- Colonization and infection of the skin by S. aureus: immune system evasion and the response to cationic antimicrobial peptides.International journal of molecular sciences · 2014Review
- Toll-like receptors and skin cancer.Frontiers in immunology · 2014Review
- Effects of yoga exercise on salivary beta-defensin 2.European journal of applied physiology · 2013Article
- Effects of High-Intensity Endurance Exercise on Epidermal Barriers against Microbial Invasion.Journal of sports science & medicine · 2013Article
- Innate and adaptive immune responses against Staphylococcus aureus skin infections.Seminars in immunopathology · 2012Review
- Activation of TLR2 by a small molecule produced by Staphylococcus epidermidis increases antimicrobial defense against bacterial skin infections.The Journal of investigative dermatology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Human beta defensin 2 (hbetaD-2) is thought to play an important role in cutaneous immune defense. We hypothesized that (i) keratinocyte expression of hbetaD-2, measured by reverse transcription-PCR, would be upregulated in response to challenge with pathogenic bacteria, particularly highly adherent strains of Streptococcus pyogenes and Staphylococcus aureus, and (ii) hbetaD-2 would have potent antimicrobial activity against pathogenic but not commensal organisms. Expression of hbetaD-2 was induced consistently by S. aureus, Staphylococcus epidermidis, Escherichia coli, and Pseudomonas aeruginosa, whereas strains of S. pyogenes were poor and variable inducers of hbetaD-2. No correlation was found between levels of bacterial adherence and keratinocyte expression of hbetaD-2. S. pyogenes was significantly more sensitive to killing by hbetaD-2 than S. epidermidis. We conclude that the ability to induce hbetaD-2 expression in combination with sensitivity to its antimicrobial effects may contribute to the rarity of skin infections with the gram-negative bacterial organisms, whereas lack of stimulation of hbetaD-2 expression by S. pyogenes may be important in its ability to evade innate defenses and cause skin disease. Induction of expression of hbetaD-2 but relative tolerance to it may enable S. epidermidis to survive on the skin surface and modulate hbetaD-2 expression when the stratum corneum barrier is disrupted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.