ArticleMolecular biology and evolution2003
The esterase and PHD domains in CR1-like non-LTR retrotransposons.
Article in Molecular biology and evolution, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 76 citations in OpenAlex.
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- Capture of a functionally active methyl-CpG binding domain by an arthropod retrotransposon family.Genome research · 2019Article
- Distribution of CR1-like transposable element in woodpeckers (Aves Piciformes): Z sex chromosomes can act as a refuge for transposable elements.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2018Article
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- A conserved role for the ESCRT membrane budding complex in LINE retrotransposition.PLoS genetics · 2017Article
- LTR-Retrotransposons from Bdelloid Rotifers Capture Additional ORFs Shared between Highly Diverse Retroelement Types.Viruses · 2017Article
- LINEs between Species: Evolutionary Dynamics of LINE-1 Retrotransposons across the Eukaryotic Tree of Life.Genome biology and evolution · 2016Article
- The Specific Requirements for CR1 Retrotransposition Explain the Scarcity of Retrogenes in Birds.Journal of molecular evolution · 2015Article
- Multiple lineages of ancient CR1 retroposons shaped the early genome evolution of amniotes.Genome biology and evolution · 2014Article
- Integrated mechanism for the generation of the 5' junctions of LINE inserts.Nucleic acids research · 2014Article
- A multicopy Y-chromosomal SGNH hydrolase gene expressed in the testis of the platyfish has been captured and mobilized by a Helitron transposon.BMC genetics · 2014Article
- Interspecies insertion polymorphism analysis reveals recent activity of transposable elements in extant coelacanths.PloS one · 2014Article
- Modular organization and reticulate evolution of the ORF1 of Jockey superfamily transposable elements.Mobile DNA · 2014Article
- Structure and properties of the esterase from non-LTR retrotransposons suggest a role for lipids in retrotransposition.Nucleic acids research · 2013Article
- RNA-Mediated Gene Duplication and Retroposons: Retrogenes, LINEs, SINEs, and Sequence Specificity.International journal of evolutionary biology · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Most active non-LTR (long terminal repeat) retrotransposons carry two open reading frames (ORFs) encoding ORF1p and ORF2p proteins. The ORF2p proteins are relatively well studied and are known to contain endonuclease/reverse transcriptase domains. At the same time, the biological function of ORF1p proteins remains poorly understood, except in that they nonspecifically bind single-stranded mRNA/DNA molecules. CR1-like elements form the most widely distributed clade/superfamily of non-LTR retrotransposons. We found that ORF1p proteins encoded by diverse CR1-like elements contain conserved esterase domain (ES) or plant homeodomain (PHD). This indicates that CR1-like ORF1p proteins are either lipolytic enzymes or are involved in protein-protein interactions related to chromatin remodeling. Sequence conservation of ES suggests that interaction with cellular membranes is an important phase in life circles of CR1-like elements. Presumably such interaction helps in penetrating host cells. As a consequence, the presence of multiple young CR1 families characterized by approximately 10% intrafamily and 40% interfamily identities may be explained by a relatively frequent horizontal transfer of these CR1-like elements. Unexpectedly, ES links together non-LTR retrotransposons and single-stranded RNA viruses like influenza C and coronaviruses, which are known to depend on their own ES.
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