ArticleClinical and experimental immunology2003
The role of somatic mutation in determining the affinity of anti-DNA antibodies.
Article in Clinical and experimental immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Characterization of an anti-fetal AChR monoclonal antibody isolated from a myasthenia gravis patient.Scientific reports · 2017Article
- Inhibition of preS1-hepatocyte interaction by an array of recombinant human antibodies from naturally recovered individuals.Scientific reports · 2016Article
- An entity evolving into a community: defining the common ancestor and evolutionary trajectory of chronic lymphocytic leukemia stereotyped subset #4.Molecular medicine (Cambridge, Mass.) · 2015Article
- Temporal dynamics of clonal evolution in chronic lymphocytic leukemia with stereotyped IGHV4-34/IGKV2-30 antigen receptors: longitudinal immunogenetic evidence.Molecular medicine (Cambridge, Mass.) · 2013Article
- B cells in autoimmune diseases: insights from analyses of immunoglobulin variable (Ig V) gene usage.Autoimmunity reviews · 2007Review
- Specificity and overlap in gene segment-defined antibody repertoires.BMC genomics · 2005Article
- Problems in using statistical analysis of replacement and silent mutations in antibody genes for determining antigen-driven affinity selection.Immunology · 2005Article
- The critical role of arginine residues in the binding of human monoclonal antibodies to cardiolipin.Arthritis research & therapy · 2005Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Combinatorial antibody libraries were constructed from the spleen of a patient with concomitant systemic lupus erythematosus and idiopathic thrombocytopenia. Following selection of the libraries with DNA, a panel of 15 anti-DNA Fabs was isolated. Sequence analysis of these antibodies coupled with measurements of their affinities for ss- and dsDNA were used to investigate the role of somatic mutation in affinity maturation of the anti-DNA response. Examination of the germline genes used by these Fabs supports previous studies that suggest there is no restriction of the gene usage in the anti-DNA response. However, data are presented indicating that VH3 genes and the A27 V(kappa) paired with the J(kappa)1 may be over-expressed in the anti-DNA repertoire. Analysis of the role of somatic mutation in increasing affinity for DNA indicates that affinity maturation has occurred and suggests that the CDR1 and CDR2 of the heavy chain are of importance in this process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.